The Clinical Compendium & Board Handbook
The complete clinical reference library across 105 high-yield chapters. Covers allopathic clinical medicine alongside deep osteopathic biomechanics, diagnostic algorithms, and pharmacology with interactive semantic word linking.
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Volume 1: Osteopathic Manipulative Medicine & Biomechanics
18 comprehensive chapters from TART foundations to sacral torsions, SBS strains, and orthopedic tests.
OMM Foundations, TART & Spinal Biomechanics
The Philosophical Tenets, Five Models of Care, Somatic Dysfunction Neurophysiology, Fryette Kinematics & Motion Barrier Dynamics
Cervical Spine, Suboccipital Kinematics & Cranial Junctions (OA, AA, C2–C7)
Occipitoatlantal Nodding Mechanics, Atlantoaxial Pure Rotation, Uncovertebral Joints of Luschka, Vertebrobasilar Safety & Thoracic Outlet Entrapments
Thoracic Spine, Ribcage Mechanics & Respiratory Kinematics
The Rule of Threes, Pump-Handle vs. Bucket-Handle Kinematics, Inhalation/Exhalation Key Rib Algorithms & Sympathetic Chain Rib Raising
Lumbar Spine, Intervertebral Disc Pathology & Radiculopathy
Sagittal Facet Mechanics, Ferguson's Lumbosacral Angle, The Psoas Syndrome Triad, Spondylolysis vs. Spondylolisthesis & L4–S1 Radiculopathy
Pelvis, Sacrum & Innominate Kinematics
The 4 Sacral Axes, The Step-by-Step Torsion Diagnostic Algorithm, L5 Kinematic Counter-Rotation & Innominate Rotations/Shears
Upper & Lower Extremity Dysfunctions & Entrapment Neuropathies
Carrying Angle Biomechanics, Radial & Fibular Head Kinematics, Rotator Cuff Functional Anatomy & Peripheral Nerve Entrapments
Osteopathy in the Cranial Field (OCF) & Craniosacral Kinematics
Sutherland's Five PRM Components, SBS Physiological & Non-Physiological Strains, Vault Hold Finger Placement & Craniosacral Decompression
Autonomic Nervous System & Viscerosomatic Reflex Mapping
Sympathetic T1–L2 Outflow, Collateral Prevertebral Ganglia, Parasympathetic Vagal vs. S2–S4 Boundaries & Normalization Techniques
Chapman Neurolymphatic Reflex Points & Visceral Diagnosis
Histopathology of Neurolymphatic Nodules, Diagnostic Palpation Mechanics & The Master Anterior and Posterior Anatomic Catalog
OMT Treatment Modalities: Mechanics, Neurophysiology & Contraindications
The Direct vs. Indirect Taxonomy, Muscle Energy Autogenic/Reciprocal Inhibition, Counterstrain Gamma Loop Reset & HVLA Localization
Clinical Orthopedic Examination: Special Tests & MSK Discriminators
Provocative Physical Exam Maneuvers, Diagnostic Sensitivity/Specificity & MSK Clinical Discriminators for Shoulder, Knee, Hip and Spine
Lymphatic System Anatomy, Transverse Diaphragms & Treatment Protocols
Terminal Drainage Territories, The 4 Transverse Diaphragms, The Strict 4-Step Treatment Sequence & Clinical Contraindications
Scoliosis, Postural Decompensation, Short Leg Syndrome & Heel Lifts
Structural vs. Functional Curves, Cobb Angle Management, Short Leg Biomechanical Cascade & The Strict Heel Lift Prescribing Protocol
Complete Jones Counterstrain Tenderpoint Atlas & Positioning
Neurophysiology of the Gamma Motor Neuron Loop, Cervical, Thoracic, Rib, Lumbar, Pelvic, Sacral & Extremity Tenderpoint Maps and Exact F/E/S/R Treatment Positions
Step-by-Step OMT Positioning & Localization Master Atlas
Direct vs. Indirect Barrier Localization, High-Velocity Low-Amplitude (HVLA), Muscle Energy Technique (MET), Still Technique, Facilitated Positional Release (FPR), Balanced Ligamentous Tension (BLT) & Myofascial Release (MFR) Across All 10 Body Regions
Gait Cycle Kinematics, Postural Decompensation, Obstetric/Pregnancy OMT, Pediatric OMM & Hospitalized Post-Operative OMT Protocols
Stance vs. Swing Gait Biomechanics, Q-Angle & Carrying Angle, Trimester-Specific Obstetric OMT & Contraindications, Pediatric Cranial/Otitis Media OMM, and Postoperative Ileus & Inpatient Pulmonary Protocols
Advanced Lumbo-Pelvic-Sacral Differential Diagnosis, Pubic Shear/Innominate Rotation Matrices & Craniosacral-Autonomic Coupling
Standing vs. Seated Flexion Test Lateralization, ASIS/PSIS/Malleolus Landmark Matrices, Pubic Symphysis Shotgun Priority, Complete 10-Pattern Sacral Matrix, L5 Rules of Three & Craniosacral Core Link Mechanics
Organ-System OMT Prescription Algorithms: Cardiopulmonary, GI, Renal, OB/GYN, ENT & Post-Concussion Osteopathic Care
Comprehensive Viscerosomatic, Parasympathetic, Chapman Reflex & Lymphatic Sequencing Algorithms Across HEENT/Sinusitis, Cardiopulmonary, Foregut/Midgut/Hindgut GI, and Genitourinary/Pelvic Systems
Volume 2: Organ System Clinical Pathology
60 core disease chapters with evidence-based diagnostics, acute resuscitation protocols, and OMM correlates.
Acute Coronary Syndromes (STEMI, NSTEMI, Unstable Angina)
Pathophysiology, plaque rupture, 12-lead ECG localization, cardiac biomarkers, dual antiplatelet therapy, and revascularization protocols.
Heart Failure & Cardiomyopathies (HFrEF, HFpEF, GDMT)
Pathophysiology of ventricular remodeling, ACC/AHA stages, NYHA functional classes, guideline-directed medical therapy quadruplet, and acute decompensated HF.
Pulmonary Embolism & Venous Thromboembolism
Virchow triad, Wells criteria, PERC rule, CTA vs V/Q scanning, emergent anticoagulation, and systemic thrombolysis for massive PE.
Asthma & Chronic Obstructive Pulmonary Disease (COPD)
Spirometry criteria, GOLD classifications, stepwise asthma therapy, acute exacerbation protocols, and non-invasive positive pressure ventilation.
Acute Abdomen, Pancreatitis & Biliary Emergencies
Charcot triad, Reynolds pentad, Ranson criteria, biliary colic vs cholecystitis, mesenteric ischemia, and celiac/mesenteric ganglion reflexes.
Acute Kidney Injury & Acid-Base Disorders
Prerenal azotemia vs ATN, FeNa calculation, urine microscopy sediment, Winter's formula, and metabolic anion gap differentials.
Diabetic Ketoacidosis (DKA) & HHS
Insulin deficiency, beta-hydroxybutyrate ketogenesis, fluid resuscitation, potassium shift dynamics, and cerebral edema prevention.
Acute Stroke & Intracranial Hemorrhage
Non-contrast head CT, IV alteplase eligibility criteria, mechanical thrombectomy, vascular territory syndromes (MCA, ACA, PCA), and SAH management.
Sepsis, Septic Shock & Hemodynamic Profiles
Sepsis-3 definitions, SOFA vs qSOFA scores, Surviving Sepsis Campaign 1-hour bundle, vasopressor selection, and hemodynamic shock profiles.
Obstetric Emergencies & Hypertensive Disorders of Pregnancy
Preeclampsia with severe features, HELLP syndrome, eclamptic seizures, postpartum hemorrhage 4 Ts, and shoulder dystocia HELPERR algorithm.
Thyroid Storm, Myxedema Coma & Adrenal Crisis
Endocrine emergencies: Burch-Wartofsky score, PTU vs. methimazole, hydrocortisone stress dosing, and hypercalcemic crisis.
Cirrhosis, Portal Hypertension & Hepatic Encephalopathy
End-stage liver disease: SAAG calculation, spontaneous bacterial peritonitis (SBP), variceal hemorrhage, and lactulose titration.
Inflammatory Bowel Disease (Crohn Disease vs. Ulcerative Colitis)
Transmural skip lesions vs. continuous mucosal inflammation, toxic megacolon, extraintestinal manifestations, and colonoscopy screening.
Nephritic vs. Nephrotic Syndromes & Glomerulonephritis
Proteinuria > 3.5 g/day vs. hematuria with RBC casts, post-streptococcal GN, IgA nephropathy, membranous nephropathy, and FSGS.
Workup of Microcytic, Normocytic & Macrocytic Anemias
MCV-based algorithmic approach: ferritin vs. TIBC, hemoglobin electrophoresis, reticulocyte index, and B12 vs. folate deficiency.
Acute & Chronic Leukemias and Lymphomas
Auer rods, Philadelphia chromosome t(9;22), Smudge cells, Reed-Sternberg cells, and tumor lysis syndrome prophylaxis.
Infective Endocarditis & Acute Bacterial Meningitis
Modified Duke criteria, empiric valve regimens, LP interpretation, opening pressure, and dexamethasone prior to antibiotics.
Seizure Classification, Status Epilepticus & Neuromuscular Disorders
Focal vs. generalized seizures, emergent status epilepticus protocol (IV lorazepam then levetiracetam), and Myasthenia Gravis vs. Lambert-Eaton.
Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis & Gout
Autoantibody profiles (ANA, anti-dsDNA, anti-Smith, anti-CCP), joint erosions vs. non-erosive arthritis, and synovial fluid crystal analysis.
Pediatric Exanthems, Congenital Defects & Neonatal Jaundice
Measles vs. Rubella vs. Roseola vs. Erythema Infectiosum, cyanotic 5 Ts heart defects, and unconjugated vs. conjugated hyperbilirubinemia.
Major Depressive Disorder, Bipolar Disorder & Schizophrenia
SIGECAPS criteria, Bipolar I (mania >= 7 days) vs. Bipolar II (hypomania + MDD), positive vs. negative psychotic symptoms, and suicide risk stratification.
Valvular Heart Diseases & Dynamic Auscultation
Aortic Stenosis, Aortic Regurgitation, Mitral Stenosis, Mitral Regurgitation, and physical maneuver variations.
Cardiac Arrhythmias, Heart Blocks & ECG Interpretation
Atrial Fibrillation, Atrial Flutter, SVT/AVNRT, Ventricular Tachycardia, and 1st, 2nd, and 3rd Degree AV Blocks.
Hypertensive Crises, Acute Pericarditis & Cardiac Tamponade
Hypertensive Urgency vs. Emergency, Beck's Triad, Pulsus Paradoxus, and PR-segment ECG changes.
Pneumonias, Atypical Pathogens & Pulmonary Infiltrates
Community-Acquired vs. Hospital-Acquired Pneumonia, CURB-65 criteria, Legionella, Mycoplasma, and Pneumocystis jirovecii.
Interstitial Lung Diseases, Pleural Effusions & Lung Malignancies
Idiopathic Pulmonary Fibrosis, Sarcoidosis, Light's Criteria for Effusions, Tension Pneumothorax, and Bronchogenic Carcinoma.
Esophageal Dysmotility, PUD & Gastric Neoplasms
GERD, Barrett Esophagus, Achalasia, Diffuse Esophageal Spasm, Peptic Ulcer Disease, and H. pylori Eradication.
Biliary Tract Pathologies & Viral Hepatitis
Cholelithiasis, Acute Cholecystitis, Ascending Cholangitis (Reynolds Pentad), PSC vs. PBC, and Hepatitis B Serology.
Malabsorption, Colorectal Polyps & Colon Cancer
Celiac Disease, Whipple Disease, Adenoma-Carcinoma Sequence, Lynch Syndrome, and Screening Guidelines.
Chronic Kidney Disease, Acid-Base & Nephrolithiasis
CKD mineral bone disease, high anion gap acidosis (MUDPILES), Winter's formula, and Calcium oxalate vs. Uric acid stones.
Calcium Disorders, Pituitary Pathology & MEN Syndromes
Hypercalcemia (Stones, Bones, Groans, Psychiatric Overtones), Primary Hyperparathyroidism, Pituitary Adenomas, and MEN 1 vs. 2A vs. 2B.
Headaches, Trigeminal Neuralgia & Cranial Nerve Palsies
Migraine vs. Cluster vs. Tension Headache, Idiopathic Intracranial Hypertension, Trigeminal Neuralgia, and Bell's Palsy.
Multiple Sclerosis, Movement Disorders & Myasthenia
MS diagnosis (McDonald criteria), Parkinson vs. Huntington, Myasthenia Gravis vs. Lambert-Eaton, and Guillain-Barré.
Cognitive Decline: Dementia Subtypes vs. Delirium
Alzheimer Disease, Vascular Dementia, Lewy Body Dementia, Frontotemporal Dementia, and Normal Pressure Hydrocephalus.
Hemostasis, Platelet Disorders & Coagulopathies
ITP, TTP/HUS, DIC, von Willebrand Disease, Hemophilia A/B, and Heparin-Induced Thrombocytopenia.
HIV Medicine, Opportunistic Infections & Antiretroviral Therapy
CD4 cutoffs, primary prophylaxis (PJP, Toxoplasma, MAC), acute retroviral syndrome, immune reconstitution inflammatory syndrome (IRIS), and modern ART regimens.
Tuberculosis, Systemic Endemic Mycoses & Zoonotic Infections
Mycobacterium tuberculosis (RIPE protocol), Histoplasma, Coccidioides, Blastomyces, Lyme disease (Borrelia), Rocky Mountain Spotted Fever, and Syphilis (Treponema).
Seronegative Spondyloarthropathies & Systemic Vasculitides
Ankylosing Spondylitis, Psoriatic Arthritis, Reactive Arthritis, Giant Cell Arteritis, Takayasu, Polyarteritis Nodosa, Granulomatosis with Polyangiitis (c-ANCA), and Henoch-Schönlein Purpura.
Blistering Dermatoses, Psoriasis & Severe Cutaneous Drug Reactions
Pemphigus Vulgaris vs. Bullous Pemphigoid, Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN), Psoriasis vulgaris, and Erythema Multiforme.
Cutaneous Malignancies, Soft Tissue Infections & Viral Exanthems
Melanoma (Breslow depth, ABCDEs), Basal Cell vs. Squamous Cell Carcinoma, Cellulitis vs. Erysipelas, Necrotizing Fasciitis, Herpes Zoster, and Measles/Varicella.
Antepartum Complications, Gestational Diabetes & Alloimmunization
Gestational Diabetes (Carpenter-Coustan criteria), Rh Alloimmunization (RhoGAM protocol), Preterm Labor, Cervical Insufficiency, and Placental Insufficiency.
Gynecologic Oncology & Benign Pelvic Pathology
Cervical Cancer (HPV 16/18, Pap triage), Endometrial Cancer vs. Hyperplasia, Ovarian Neoplasms (Epithelial, Germ cell, Stromal), Endometriosis, and PCOS.
Neonatology, Cyanotic Heart Defects & Congenital Anomalies
Respiratory Distress Syndrome (RDS), Meconium Aspiration, The 5 Cyanotic Congenital Heart Diseases (5 Ts), Congenital Diaphragmatic Hernia, and Neonatal Jaundice.
Pediatric Abdominal Emergencies & Developmental Milestones
Pyloric Stenosis, Intussusception, Malrotation with Midgut Volvulus, Hirschsprung Disease, Meckel Diverticulum, and Key Developmental Milestones.
Anxiety Disorders, Personality Pathology & Substance Withdrawal
Panic Disorder, Generalized Anxiety Disorder (GAD), PTSD, Personality Clusters A/B/C, Alcohol Withdrawal (Delirium Tremens, CIWA), and Opioid Toxidrome.
Biochemistry, Bioenergetics & Inborn Errors of Metabolism
Rate-limiting metabolic enzymes, glycogen and lysosomal storage diseases, amino acidopathies, urea cycle defects, porphyrias, purine salvage, and vitamin deficiencies.
Medical Genetics, Molecular Biology & Chromosomal Syndromes
DNA repair syndromes, Mendelian and non-Mendelian inheritance, trinucleotide repeat expansions, genomic imprinting, chromosomal aneuploidies, microdeletions, and Hardy-Weinberg genetics.
Clinical Immunology, Hypersensitivity, Primary Immunodeficiencies & Transplant Rejection
Innate and adaptive immunity, MHC I and II antigen presentation, complement cascades, Types I–IV hypersensitivity, B/T/phagocyte immunodeficiencies, and transplant rejection.
General Pathology, Cellular Injury, Necrosis, Apoptosis & Neoplasia Foundations
Cellular adaptations, reversible vs. irreversible injury, six patterns of necrosis, intrinsic and extrinsic apoptosis, amyloidosis, wound healing, oncogenes, tumor suppressors, and paraneoplastic syndromes.
Trauma Resuscitation (ATLS), Burns, Hernias & Perioperative/Post-Operative Surgical Care
ATLS primary survey, thoracic and abdominal trauma algorithms, penetrating neck zones, Parkland burn resuscitation, ASA/RCRI perioperative care, post-op complications, and abdominal wall hernias.
Vascular, Breast, Endocrine & Cardiothoracic Surgery
Abdominal aortic aneurysm, Stanford A/B aortic dissection, peripheral arterial disease and acute limb ischemia, breast mass BI-RADS algorithms, benign/malignant breast pathology, and surgical endocrine disorders.
Orthopedic Trauma, Pediatric Orthopedics, Peripheral Nerve Lesions & Compartment Syndrome
Compartment syndrome, fat embolism, fracture-nerve pairings, brachial and lumbosacral plexus lesions, pediatric hip and Salter-Harris disorders, and primary bone tumors.
Urology, Scrotal Emergencies, Urologic Oncology & Voiding Dysfunction
Testicular torsion vs. epididymitis, varicocele and hydrocele, testicular and renal/bladder/prostate oncology, urinary incontinence urodynamics, urethral/bladder trauma, and priapism/Fournier gangrene.
Ophthalmology, Neuro-Ophthalmology & Otolaryngology (ENT) Emergencies
Open- vs. angle-closure glaucoma, CRAO vs. CRVO, retinal detachment, orbital vs. preseptal cellulitis, red eye differential, Weber/Rinne hearing loss, vertigo HINTS, and deep neck space infections.
Environmental Medicine, Bites, Envenomations, Thermal Injury & Dysbarism
Hypothermia and Osborn J waves, heat stroke vs. heat exhaustion, high-altitude HAPE/HACE, decompression sickness vs. gas embolism, snake and spider envenomations, rabies PEP, and PECARN head trauma.
Foundational Medical Microbiology: Bacteriology, Virology, Mycology & Parasitology
Diagnostic Laboratory Algorithms, Gram-Positive and Gram-Negative Bacteriology, Exotoxin vs. Endotoxin Mechanisms, Baltimore Virology Classification, Systemic Mycoses, and Clinical Parasitology
Foundational Organ System Physiology: Cardiac PV Loops, Wiggers Diagram, Respiratory V/Q, Renal Clearance & GI Physiology
Membrane Bioelectricity, Cardiac Action Potentials, Wiggers Hemodynamics, Left Ventricular Pressure-Volume Loops, Alveolar Gas Exchange, Renal Clearance Equations, and Gastrointestinal Peptide Hormones
High-Yield Clinical Embryology, Pharyngeal Arches/Pouches, Urogenital/Cardiac Embryology & Teratology
Germ Layer & Neural Crest Derivatives, Pharyngeal Apparatus (Arches, Pouches, Clefts), Conotruncal & Aortic Arch Development, Gastrointestinal Rotation, Mesonephric/Paramesonephric Differentiation, and Clinical Teratogens
Geriatric Medicine, Palliative & End-of-Life Care, Physical Medicine & Rehabilitation (PM&R) & Sleep Medicine
Physiology of Normal Aging, Beers Criteria Polypharmacy, Pressure Ulcer Staging, Hospice & Opioid Rotation, Autonomic Dysreflexia, Heterotopic Ossification, Polysomnography Sleep Stages, and Sleep Apnea Syndromes
ICU & Critical Care: Mechanical Ventilation Dyssynchrony, Auto-PEEP, Dysnatremias, Pacemakers, ECPR/DSED & ED Thoracotomy
ARDSnet Lung-Protective Ventilation, Ventilator Dyssynchrony Waveforms & Troubleshooting, Auto-PEEP, Severe Dysnatremias, Pacemaker/ICD Malfunctions, Refractory Cardiac Arrest (DSED/ECPR), Resuscitative Thoracotomy, Tracheostomy/Laryngectomy, and Blast/Ballistic/Toxicologic Crises
Volume 3: High-Yield Pharmacology & Clinical Toxicology
17 master drug chapters covering autonomic receptors, cardiovascular drugs, antimicrobials, endocrine agents, psychotropics, and toxidrome antidotes.
Autonomic Nervous System Drugs (Adrenergics & Cholinergics)
Sympathetic and parasympathetic receptor distribution, alpha/beta agonists and antagonists, cholinergic toxidromes (SLUDGE), and atropine reversal.
Cardiovascular Pharmacology (Antihypertensives & Antiarrhythmics)
First-line antihypertensives, Vaughan Williams antiarrhythmic classes I–IV, statin safety, and heart failure pharmacotherapy.
Antimicrobial Stewardship & Empiric Regimens
Cell wall inhibitors, ribosomal 30S/50S inhibitors, fluoroquinolone black box warnings, MRSA/Pseudomonas coverage, and antifungal mechanisms.
Clinical Toxicology, Ingestions & Antidotes Master Table
Classic ingestion toxidromes, metabolic pathways, anion gap toxic alcohols, specific receptor antidotes, and gastric decontamination.
Endocrine & Diabetes Pharmacology
Insulin regimens, Metformin, GLP-1 receptor agonists, SGLT-2 inhibitors, Sulfonylureas, and Thionamides.
Psychotropic Medications & Neuropharmacology
SSRIs, SNRIs, Bupropion, Atypical Antipsychotics, Lithium, Mood Stabilizers, and EPS management.
Neurology & Anesthetic Pharmacology
Antiepileptic drugs (AEDs), Parkinson disease therapeutics, Local anesthetics (esters vs. amides, LAST), and General inhalation/IV anesthetics (malignant hyperthermia).
Chemotherapy & Immunosuppressive Pharmacology
Cell cycle specific vs. non-specific alkylating agents, antimetabolites, microtubule inhibitors, calcineurin inhibitors, and monoclonal antibodies.
Respiratory & Gastrointestinal Pharmacology
Bronchodilators (SABA/LABA, SAMAs), Inhaled Corticosteroids, Proton Pump Inhibitors, H2 Blockers, Antiemetics, and Motility Agents.
Anticoagulants, Antiplatelets & Fibrinolytic Pharmacology
Heparin vs. LMWH, Protamine reversal, Warfarin and INR monitoring, Direct Factor Xa inhibitors, Direct Thrombin inhibitors, Antiplatelet agents, and tPA.
Analgesics, Opioids, NSAIDs & Gout Pharmacology
Non-selective NSAIDs vs. Celecoxib, Acetaminophen hepatotoxicity (NAPQI), Opioid receptor pharmacology, Gout therapies (Colchicine, Allopurinol, Febuxostat), and DMARDs.
Reproductive, Urologic & Endocrine Pharmacology
Contraception (COCs, progestin IUDs), SERMs (Tamoxifen, Raloxifene), PDE5 inhibitors, Alpha-1 blockers (Tamsulosin), 5-alpha reductase inhibitors (Finasteride), and Osteoporosis therapies.
General Pharmacokinetics, Pharmacodynamics, CYP450 Interactions & Clinical Pharmacogenomics
Bioavailability (F), volume of distribution (Vd), clearance (CL), steady-state half-life kinetics, loading vs. maintenance dosing, zero- vs. first-order elimination, urine pH ion trapping, graded and quantal dose-response curves, CYP450/P-gp interactions, and HLA/metabolic pharmacogenomics.
Antiviral (HIV, HCV, Herpes/CMV/Influenza), Systemic Antifungal & Antiparasitic Pharmacology
HIV antiretroviral regimens (INSTIs, NRTIs, NNRTIs, PIs, entry/capsid inhibitors), direct-acting HCV regimens, herpesvirus/CMV/influenza/COVID-19 antivirals, systemic polyene/azole/echinocandin antifungals, and antiprotozoal/anthelmintic pharmacology.
Monoclonal Antibodies (-mab), Checkpoint Inhibitors, Kinase Inhibitors (-nib), DMARDs & Immunosuppressants
Monoclonal antibody nomenclature (-ximab, -zumab, -umab), anti-TNF/interleukin/integrin/complement biologics, CTLA-4 and PD-1/PD-L1 immune checkpoint inhibitors, targeted oncology mAbs and small-molecule tyrosine kinase inhibitors (-nibs), and transplant calcineurin/mTOR/IMPDH immunosuppressants.
Nephron Diuretics, Dyslipidemia Pharmacology, Ophthalmic Glaucoma Drops & Dermatologic Retinoids
Segment-by-segment nephron diuretic mechanisms (acetazolamide, mannitol, loop diuretics, thiazides, K+-sparing antagonists, vaptans, SGLT2 inhibitors), lipid-lowering pharmacology (statins, ezetimibe, PCSK9 inhibitors, fibrates, niacin, icosapent ethyl), glaucoma aqueous humor drugs, and dermatologic retinoids.
Herbal Supplements, Drug-Induced Organ Toxicities, Beers Criteria & Pregnancy/Lactation Pharmacology
High-yield botanical supplements and drug interactions (St. John's wort, ginkgo, ginseng, garlic, saw palmetto, kava, black cohosh, licorice), master drug-induced organ toxicity syndromes (drug-induced lupus, Torsades de Pointes, pulmonary fibrosis, SIADH, pancreatitis), Beers Criteria geriatric polypharmacy, and safe vs. teratogenic prescribing in pregnancy.
Volume 4: Medical Jurisprudence, Ethics & Biostatistics
10 essential chapters on legal duties, consent exceptions, surrogate hierarchy, quality improvement, and board biostatistics.
Medical Jurisprudence, Consent, Capacity & Healthcare Ethics
Informed consent, decision-making capacity vs competence, Tarasoff duty to protect, end-of-life directives, and malpractice law.
Patient Safety, Quality Improvement & Root Cause Analysis
The Swiss Cheese model, latent vs active errors, near misses vs sentinel events, open disclosure protocols, and PDSA continuous improvement cycles.
High-Yield Board Biostatistics & Evidence-Based Medicine
2x2 diagnostic tables, Sensitivity, Specificity, PPV, NPV, Odds Ratio, Relative Risk, NNT/NNH, and statistical bias.
Health Systems Science, Healthcare Economics & Hospital Policy
Medicare Parts A–D, Medicaid eligibility, HMO vs. PPO insurance models, Accountable Care Organizations (ACOs), EMTALA, and Physician Impairment.
Preventive Medicine, Public Health Screening & Outbreak Investigation
USPSTF Grade A/B Screening Guidelines (Breast, Cervical, CRC, Lung, AAA, Osteoporosis), Prevention Tiers (Primary, Secondary, Tertiary, Quaternary), and Outbreak Investigation Steps.
Physician-Patient Communication, Delivering Bad News (SPIKES), Motivational Interviewing, Interpreters & Difficult Encounters
Open-ended therapeutic inquiry, NURSE empathetic validation, SPIKES bad-news protocol, Prochaska-DiClemente stages of change, OARS motivational interviewing, certified medical interpreters, transference vs. countertransference, and managing challenging clinical encounters.
Clinical Study Designs, Epidemiologic Bias Taxonomy, Confounding vs. Effect Modification, Research Ethics & Drug Ads
Hierarchy of observational and experimental study designs, Phase I–IV trials, intention-to-treat vs. per-protocol analysis, selection/information/screening biases, stratification for confounding vs. effect modification, Belmont Report ethics, and critical appraisal of pharmaceutical drug advertisements.
USPSTF Grade A/B Screening Guidelines, Pediatric/Adult Immunization Schedules, Travel Prophylaxis & Geriatric Prevention
Age- and risk-stratified USPSTF Grade A/B cancer and cardiometabolic screenings, ACIP pediatric/adolescent/adult vaccination schedules, live-attenuated vaccine contraindications, post-exposure prophylaxis, travel medicine chemoprophylaxis, and geriatric fall/polypharmacy prevention.
Occupational Medicine & Pneumoconioses, Workers Compensation, Disability, Death Certificates, Malpractice & DEA Schedules
Occupational lung diseases (asbestosis, malignant mesothelioma, silicosis, coal worker's pneumoconiosis, berylliosis, byssinosis, hypersensitivity pneumonitis), industrial carcinogens, workers' compensation, medical impairment vs. legal disability, death certificate completion, malpractice tort law (4 Ds), and DEA Controlled Substance Schedules I–V.
Diagnostic Decision Analysis: Fagan Nomograms, Sequential/Simultaneous Testing, Survival Analysis, Forest/Funnel Plots & ICER/QALYs
Bayesian pre-test to post-test probability updating, Fagan nomograms, sequential (series) vs. simultaneous (parallel) diagnostic testing, Kaplan-Meier survival curves, log-rank test, Cox proportional hazards regression, meta-analysis forest plots and funnel plots (publication bias), and pharmacoeconomic ICER/QALY modeling.