| Condition | Key Finding | Association | Board Exam Tip |
| Anorexia Nervosa | Hypophosphatemia, Amenorrhea, Low BMI (<18.5) | Refeeding Syndrome; Estrogen deficiency -> Osteoporosis | Always suspect hypophosphatemia upon refeeding in AN/severe malnutrition. |
| PTSD | Flashbacks, Avoidance, Hyperarousal | SSR Is + CBT; Nightmares -> Prazosin | Never use benzodiazepines for PTSD treatment on the board exam. |
| Bulimia Nervosa | Metabolic Alkalosis, Hypokalemia, Russell's sign | Vomiting/Diuretics (Purging); Fluoxetine (SSR Is) | The key differentiator from Binge Eating Disorder is the presence of compensatory behaviors. |
| Bipolar Disorder | Manic episode symptoms (Grandiosity, decreased sleep) | Lithium; Second-generation antipsychotics | If CKD or lithium toxicity is suspected, consider second-gen antipsychotics first. |
| Topic | Key Point | Context | Exam Relevance |
| Depression | 5+ symptoms for 2 weeks (PHQ-9) | Screening/Diagnosis of MDD | Must differentiate from normal grief reaction and bipolar depression. |
| Bipolar Disorder | Manic episode criteria | Elevated mood, grandiosity, decreased need for sleep | Always screen for mania when treating depressive symptoms to avoid missing a diagnosis. |
| Anxiety Disorders | Panic Attack vs. Panic Disorder | Unexpected recurrence of panic attacks (Panic Disorder) | Acute treatment can use benzodiazepines, but long-term therapy must be CBT + SSRI. |
| Somatic Symptoms | Somatic Symptom Disorder | Real symptom causing distress; multiple negative medical workups | Treatment focuses on reassurance and single-physician continuity of care. |
| Board-speak / Vignette phrase | Diagnosis / Concept | Why it fits |
| A patient presents with persistent, intrusive thoughts and repetitive washing rituals that cause significant distress but are recognized as unreasonable by the patient. | Obsessive-Compulsive Disorder (OCD) | The core definition requires both obsessions (intrusive thoughts) or compulsions (repetitive acts). |
| A young woman is found to have a BMI of 16 kg/m² and reports amenorrhea, with laboratory findings showing hypophosphatemia. | Anorexia Nervosa | Low BMI (<18.5), amenorrhea, and electrolyte abnormalities are classic signs of severe energy restriction and malnutrition. |
| A patient presents after a major trauma and exhibits frequent flashbacks, avoidance of reminders, and hypervigilance. | Post-Traumatic Stress Disorder (PTSD) | The triad of re-experiencing symptoms (flashbacks), avoidance, and arousal/hyperarousal defines PTSD. |
| A 35-year-old woman presents with severe anxiety about her health, spending hours researching obscure diseases, but has no objective physical signs of illness. | Illness Anxiety Disorder (Hypochondriasis) | The patient is preoccupied with potential illness without having an actual, measurable symptom. |
| A patient who frequently vomits due to purging exhibits hypokalemia and metabolic alkalosis on labs. | Bulimia Nervosa/Purging Behavior | Vomiting causes loss of stomach acid ({H Cl}), leading to {HCO}_3^- retention (alkalosis) and potassium loss (hypokalemia). |
| A patient with a history of hypertension is being treated for ADHD, and the clinician must choose an agent that does not increase cardiovascular risk. | Atomoxetine (SNRI) | Stimulants (methylphenidate/amphetamine) can exacerbate hypertension; atomoxetine is a safer alternative SNRI choice. |
| Key Features | Distinguishing Findings | Next Step |
| Excessive, pervasive worry about multiple life domains (e.g., finances, health). | Worry is generalized and chronic; not tied to specific performance/social situations. | CBT + SSRI/SNRI or Buspirone. |
| Key Features | Distinguishing Findings | Next Step |
| Real symptom causing distress; multiple negative workups; patient is highly invested in the illness narrative. | Illness Anxiety: Worry about potential illness, no actual symptoms. Malingering: Symptoms for external gain (e.g., avoiding court). | Establish a therapeutic alliance with one physician and use CBT/reassurance. |
| Key Features | Distinguishing Findings | Next Step |
| Binge eating followed by compensatory behaviors (purging, laxatives, excessive exercise). | Bulimia Nervosa: Compensatory behaviors present. Binge Eating Disorder: No compensatory behaviors. | Treat with CBT + SSRI; monitor electrolytes and cardiac status closely. |
| Condition | Association | Mechanism | Clinical Significance |
| Anorexia Nervosa | Low Estrogen -> Osteoporosis | Lack of estrogen leads to decreased osteoprotegerin, resulting in increased bone resorption. | High risk for skeletal complications; requires careful monitoring of calcium/Vitamin D. |
| Bulimia Nervosa | Vomiting/Purging | Loss of gastric acid ({H Cl}) and potassium ({K}^+). | Leads to metabolic alkalosis and hypokalemia, requiring aggressive electrolyte replacement. |
| PTSD | Nightmares -> Prazosin | Alpha-1 adrenergic receptor blockade (vasodilation/sedative effect on sympathetic tone). | Prazosin is the preferred agent for reducing frequency and severity of trauma-related nightmares. |
| ADHD | Stimulants vs. Non-stimulants | Methylphenidate/Amphetamine increase dopamine/norepinephrine; Atomoxetine inhibits norepinephrine reuptake (SNRI). | Use non-stimulants like atomoxetine if the patient has cardiovascular risks (e.g., hypertension, CAD). |
| Term | Definition | Context | Example |
| PHQ-2/9 | Patient Health Questionnaire; screening tool for depression. | Initial assessment of depressive symptoms in primary care. | Asking "Over the past two weeks, have you felt down or hopeless?" |
| Avolition | Lack of motivation or inability to initiate goal-directed activities. | Negative symptom of schizophrenia. | A patient who stares blankly and cannot get out of bed without prompting. |
| Malingering | Faking symptoms for external, tangible gain (e.g., avoiding work/court). | Differential diagnosis in somatic complaints. | Feigning weakness to avoid physical labor on a construction site. |
| Hyperarousal | State of heightened vigilance and exaggerated startle response. | Core symptom of PTSD. | Jumping at loud noises or sudden movements; difficulty sleeping. |
| Topic | Study Approach | Priority | Resources |
| Mood Disorders | Focus on differential diagnosis (MDD vs Bipolar) and specific drug side effects/contraindications. | High | Review the full spectrum of mood disorders, paying attention to cyclical patterns. |
| Anxiety & Trauma | Memorize key treatment algorithms: CBT + SSRI; Prazosin for PTSD nightmares. | Medium-High | Use flowcharts to distinguish between panic attack and panic disorder management. |
| Eating Disorders | Master the physiological consequences (electrolytes, bone density) of AN/BN. | High | Link low BMI -> Estrogen deficiency -> Osteoporosis; Vomiting -> Alkalosis/Hypokalemia. |