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Source / episode info

  • Episode: 209
  • Title: Divine Intervention Episode 209 – Family Medicine Shelf Review Series 2.
  • Published: 2020-02-10
  • Source: Episode page

One-liner

This episode provides a comprehensive review of common psychiatric disorders tested on Family Medicine shelf exams, covering depression screening/treatment, bipolar spectrum disorders, anxiety (GAD, panic), somatic symptom differentials, eating disorders (AN, BN), PTSD, OCD, and ADHD management.

High-yield summary

  • Depression Screening: Use the PHQ-2 or PHQ-9 questions ("over the past two weeks, have you felt down/depressed or hopeless?" / "little interest or pleasure in doing things?") to screen for Major Depressive Disorder (MDD).
  • Bipolar Management: If a patient has MDD symptoms but a history of manic episodes, consider Bipolar Disorder. Treatment often involves Lithium; monitor for nephrogenic diabetes insipidus and hypothyroidism.
  • Anorexia Nervosa Complications: Due to severe malnutrition and low estrogen, patients are at high risk for osteoporosis, hypophosphatemia (especially upon refeeding), metabolic alkalosis, and dangerous cardiac arrhythmias.
  • PTSD Treatment: First-line treatment is SSR Is + CBT. For nightmares, Prazosin is the drug of choice; never use benzodiazepines.
  • Somatic Symptom Differential: Differentiate between Somatic Symptom Disorder (real symptom causing distress), Illness Anxiety Disorder (excessive worry about health without symptoms), Malingering (secondary gain for external benefit), and Factitious Disorder (self-inflicted symptoms for internal gratification).
  • Eating Disorder Management: For Bulimia Nervosa, treatment involves CBT + SSRI (Fluoxetine is often preferred); the key differentiator from Binge Eating Disorder is the presence of compensatory behaviors.

Learning objectives

  • Master the screening tools and diagnostic criteria for major mood disorders, including MDD, Bipolar Disorder, and Seasonal Affective Disorder.
  • Differentiate between various anxiety spectrum disorders (GAD, Panic Disorder, Social Anxiety) and their appropriate pharmacological/psychotherapeutic treatments.
  • Recognize the key physiological complications of severe eating disorders (AN, BN), particularly electrolyte imbalances and cardiac risks.
  • Apply knowledge of psychopharmacology to treat specific conditions like OCD, PTSD, and ADHD, including recognizing drug side effects and contraindications.
  • Differentiate between various somatic symptom differentials (e.g., Malingering vs. Factitious Disorder vs. Conversion Disorder).

Board exam buzzwords

ConditionKey FindingAssociationBoard Exam Tip
Anorexia NervosaHypophosphatemia, Amenorrhea, Low BMI (<18.5)Refeeding Syndrome; Estrogen deficiency -> OsteoporosisAlways suspect hypophosphatemia upon refeeding in AN/severe malnutrition.
PTSDFlashbacks, Avoidance, HyperarousalSSR Is + CBT; Nightmares -> PrazosinNever use benzodiazepines for PTSD treatment on the board exam.
Bulimia NervosaMetabolic Alkalosis, Hypokalemia, Russell's signVomiting/Diuretics (Purging); Fluoxetine (SSR Is)The key differentiator from Binge Eating Disorder is the presence of compensatory behaviors.
Bipolar DisorderManic episode symptoms (Grandiosity, decreased sleep)Lithium; Second-generation antipsychoticsIf CKD or lithium toxicity is suspected, consider second-gen antipsychotics first.

Rapid review table

TopicKey PointContextExam Relevance
Depression5+ symptoms for 2 weeks (PHQ-9)Screening/Diagnosis of MDDMust differentiate from normal grief reaction and bipolar depression.
Bipolar DisorderManic episode criteriaElevated mood, grandiosity, decreased need for sleepAlways screen for mania when treating depressive symptoms to avoid missing a diagnosis.
Anxiety DisordersPanic Attack vs. Panic DisorderUnexpected recurrence of panic attacks (Panic Disorder)Acute treatment can use benzodiazepines, but long-term therapy must be CBT + SSRI.
Somatic SymptomsSomatic Symptom DisorderReal symptom causing distress; multiple negative medical workupsTreatment focuses on reassurance and single-physician continuity of care.

Board-speak -> diagnosis

Board-speak / Vignette phraseDiagnosis / ConceptWhy it fits
A patient presents with persistent, intrusive thoughts and repetitive washing rituals that cause significant distress but are recognized as unreasonable by the patient.Obsessive-Compulsive Disorder (OCD)The core definition requires both obsessions (intrusive thoughts) or compulsions (repetitive acts).
A young woman is found to have a BMI of 16 kg/m² and reports amenorrhea, with laboratory findings showing hypophosphatemia.Anorexia NervosaLow BMI (<18.5), amenorrhea, and electrolyte abnormalities are classic signs of severe energy restriction and malnutrition.
A patient presents after a major trauma and exhibits frequent flashbacks, avoidance of reminders, and hypervigilance.Post-Traumatic Stress Disorder (PTSD)The triad of re-experiencing symptoms (flashbacks), avoidance, and arousal/hyperarousal defines PTSD.
A 35-year-old woman presents with severe anxiety about her health, spending hours researching obscure diseases, but has no objective physical signs of illness.Illness Anxiety Disorder (Hypochondriasis)The patient is preoccupied with potential illness without having an actual, measurable symptom.
A patient who frequently vomits due to purging exhibits hypokalemia and metabolic alkalosis on labs.Bulimia Nervosa/Purging BehaviorVomiting causes loss of stomach acid ({H Cl}), leading to {HCO}_3^- retention (alkalosis) and potassium loss (hypokalemia).
A patient with a history of hypertension is being treated for ADHD, and the clinician must choose an agent that does not increase cardiovascular risk.Atomoxetine (SNRI)Stimulants (methylphenidate/amphetamine) can exacerbate hypertension; atomoxetine is a safer alternative SNRI choice.

Differential diagnosis / distinguishing features

Anxiety Disorders (GAD vs Social Anxiety)

Key FeaturesDistinguishing FindingsNext Step
Excessive, pervasive worry about multiple life domains (e.g., finances, health).Worry is generalized and chronic; not tied to specific performance/social situations.CBT + SSRI/SNRI or Buspirone.

Somatic Symptom Disorders

Key FeaturesDistinguishing FindingsNext Step
Real symptom causing distress; multiple negative workups; patient is highly invested in the illness narrative.Illness Anxiety: Worry about potential illness, no actual symptoms. Malingering: Symptoms for external gain (e.g., avoiding court).Establish a therapeutic alliance with one physician and use CBT/reassurance.

Eating Disorders

Key FeaturesDistinguishing FindingsNext Step
Binge eating followed by compensatory behaviors (purging, laxatives, excessive exercise).Bulimia Nervosa: Compensatory behaviors present. Binge Eating Disorder: No compensatory behaviors.Treat with CBT + SSRI; monitor electrolytes and cardiac status closely.

Management pearls

  • For any patient presenting with depressive symptoms, always screen for bipolar disorder history to avoid misdiagnosis (treating Bipolar Depression as MDD).
  • When managing a patient with PTSD nightmares, Prazosin is the preferred agent due to its alpha-1 adrenergic blockade properties.
  • In cases of severe malnutrition (AN), monitor for hypophosphatemia and administer IV phosphate supplementation upon refeeding initiation.
  • For patients with suspected OCD, combine SSR Is (first line) with Cognitive Behavioral Therapy (CBT), specifically Exposure and Response Prevention (ERP).

Don't miss

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Bipolar Disorder: Never assume MDD if manic symptoms are present in the history; always screen for bipolarity.
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PTSD: The use of benzodiazepines is contraindicated for long-term PTSD management due to risk of dependence/abuse.
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Anorexia Nervosa: Refeeding syndrome is a medical emergency, primarily caused by profound shifts in phosphate and potassium levels.
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Somatic Symptom Disorder: Treatment success relies on establishing continuity of care with one physician to prevent the patient from seeking multiple opinions (which can exacerbate symptoms).

Integration & clinical reasoning

  • Psychiatry & Internal Medicine: Many psychiatric presentations (e.g., depression, anxiety) are exacerbated or mimicked by underlying medical conditions (hypothyroidism, Cushing syndrome, electrolyte imbalances). Always rule out organic causes first.
  • Pharmacology & Metabolism: Understanding the mechanism of action for psychotropics is critical; e.g., SSR Is increase serotonin availability, while lithium affects renal tubular function.
  • Psychiatry & Family Medicine: The family physician plays a essential role in initial screening (PHQ-2/9) and managing stable chronic conditions, knowing when to refer to specialized psychiatry care (e.g., acute mania, psychosis).

OMM / COMLEX integration

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For COMLEX: know these viscerosomatics / Chapman points, but don't let OMM distract from emergent diagnosis and management.
  • Standard emergency management takes priority in acute psychiatric crises (e.g., suicidal ideation requires immediate hospitalization and consultation). OMT is adjunctive only after stabilization.
  • When managing severe metabolic derangements (hypophosphatemia, hypokalemia), standard critical care protocols for electrolyte replacement take precedence over any manual or physical therapy interventions.

Concept connections / cross-references

  • For detailed information on endocrine disorders that can mimic psychiatric symptoms (e.g., hypothyroidism), see [Episode 15].
  • For general guidelines on metabolic derangements related to GI losses (e.g., hypokalemia/metabolic alkalosis), review [Episode 203].

High-yield association table

ConditionAssociationMechanismClinical Significance
Anorexia NervosaLow Estrogen -> OsteoporosisLack of estrogen leads to decreased osteoprotegerin, resulting in increased bone resorption.High risk for skeletal complications; requires careful monitoring of calcium/Vitamin D.
Bulimia NervosaVomiting/PurgingLoss of gastric acid ({H Cl}) and potassium ({K}^+).Leads to metabolic alkalosis and hypokalemia, requiring aggressive electrolyte replacement.
PTSDNightmares -> PrazosinAlpha-1 adrenergic receptor blockade (vasodilation/sedative effect on sympathetic tone).Prazosin is the preferred agent for reducing frequency and severity of trauma-related nightmares.
ADHDStimulants vs. Non-stimulantsMethylphenidate/Amphetamine increase dopamine/norepinephrine; Atomoxetine inhibits norepinephrine reuptake (SNRI).Use non-stimulants like atomoxetine if the patient has cardiovascular risks (e.g., hypertension, CAD).

Key terms glossary

TermDefinitionContextExample
PHQ-2/9Patient Health Questionnaire; screening tool for depression.Initial assessment of depressive symptoms in primary care.Asking "Over the past two weeks, have you felt down or hopeless?"
AvolitionLack of motivation or inability to initiate goal-directed activities.Negative symptom of schizophrenia.A patient who stares blankly and cannot get out of bed without prompting.
MalingeringFaking symptoms for external, tangible gain (e.g., avoiding work/court).Differential diagnosis in somatic complaints.Feigning weakness to avoid physical labor on a construction site.
HyperarousalState of heightened vigilance and exaggerated startle response.Core symptom of PTSD.Jumping at loud noises or sudden movements; difficulty sleeping.

Study optimization

TopicStudy ApproachPriorityResources
Mood DisordersFocus on differential diagnosis (MDD vs Bipolar) and specific drug side effects/contraindications.HighReview the full spectrum of mood disorders, paying attention to cyclical patterns.
Anxiety & TraumaMemorize key treatment algorithms: CBT + SSRI; Prazosin for PTSD nightmares.Medium-HighUse flowcharts to distinguish between panic attack and panic disorder management.
Eating DisordersMaster the physiological consequences (electrolytes, bone density) of AN/BN.HighLink low BMI -> Estrogen deficiency -> Osteoporosis; Vomiting -> Alkalosis/Hypokalemia.

Question pattern recognition

  • Pattern: Patient presents with persistent worry about multiple life domains and restlessness. -> Generalized Anxiety Disorder (GAD). Treatment: CBT + SSRI/SNRI or Buspirone.
  • Pattern: Young patient presenting with motor deficits (e.g., weakness, paralysis) that cannot be explained by medical findings. -> Conversion Disorder. This is a functional neurological symptom disorder.
  • Pattern: Patient has symptoms of depression but also reports periods of extreme energy, grandiosity, and decreased need for sleep. -> Bipolar Disorder. Always rule out mania/hypomania first.

Test yourself

Common mistakes to avoid

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Mistake 1: Confusing MDD and Bipolar Disorder. Never assume depression is unipolar. Always screen for a history of mania/hypomania when treating depressive symptoms.
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Mistake 2: Mismanaging Electrolytes in AN/BN. Remember that refeeding syndrome can cause hypophosphatemia, which is the most dangerous electrolyte imbalance to correct slowly.
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Mistake 3: Using Benzodiazepines for PTSD. Long-term benzodiazepine use is contraindicated in PTSD due to high risk of dependence and poor outcomes.

Common traps

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Trap 1 (Bipolar): If a patient has depressive symptoms but reports past manic episodes, the diagnosis is Bipolar Disorder, not MDD.
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Trap 2 (Somatic Symptoms): The key difference between Malingering (external gain) and Factitious Disorder (internal gratification/role play) must be recognized.
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Trap 3 (ADHD): If a patient with ADHD also has hypertension or CAD, prefer Atomoxetine (SNRI) over stimulants to minimize cardiovascular risk.