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Episode Notes

Source / episode info

  • Episode: 559
  • Title: DIP Ep 559: 2024 USMLE Step 3 Free 137 Discussion Part 6b (Q55-60, super helpful for Step 2!)
  • Published: 2025-01-12
  • Source: Episode page

One-liner

This episode provides high-yield clinical reasoning on diagnosing pulmonary embolism (PE) in the setting of acute dyspnea; identifying pre-renal azotemia due to volume depletion; applying ethical principles regarding patient autonomy and surrogate decision making; recognizing pressure ulcer pathophysiology; and managing acutely ill, cognitively impaired elderly patients.

High-yield summary

  • Pulmonary Embolism (PE): Acute onset of dyspnea/tachycardia with markedly elevated D-dimer, especially when cardiac enzymes are normal and CXR is unremarkable, strongly suggests PE. Rule out common mimics like COPD exacerbation or heart failure first.
  • Pre-renal AKI: Characterized by oliguria, concentrated urine (high specific gravity), and signs of volume depletion (e.g., vomiting/diarrhea). Labs show rising BUN and creatinine due to decreased GFR from reduced renal perfusion pressure.
  • Ethical Principles in Medicine: In non-emergent settings, utilize the "reliable historian" principle by contacting primary care physicians or pharmacists for medication reconciliation rather than relying on family members or assuming emergency action is needed.
  • Patient Autonomy (DNR/Advanced Directives): A patient's current, lucidly expressed wishes regarding life support (e.g., refusing dialysis) supersede the recommendations of a surrogate decision maker (daughter/proxy).
  • Pressure Ulcers: These are caused by prolonged immobility and pressure ischemia. If an ulcer progresses to muscle or bone, debridement is mandatory; do not rely on memorizing specific staging criteria for board questions.

Learning objectives

  • Differentiate the clinical presentation of PE from other causes of acute dyspnea.
  • Identify laboratory and physical exam findings indicative of pre-renal AKI versus intrinsic renal failure.
  • Apply ethical principles (autonomy, reliable historian) to complex patient management scenarios in medicine.
  • Recognize the pathophysiology and required management steps for pressure ulcers.
  • Understand the hierarchy of decision-making regarding life support when a patient's capacity is compromised.

Board exam buzzwords

ConditionKey FindingAssociationBoard Exam Tip
Pulmonary Embolism (PE)Acute dyspnea, Tachycardia, High D-dimerDeep vein thrombosis (DVT), Atrial fibrillation (A Fib)If the clinical suspicion is high and labs are inconclusive, consider imaging (CTPA).
Pre-renal AKIOliguria, Concentrated urine specific gravity (>1.030), Rising BUN/Cr ratioVolume depletion (vomiting, diarrhea, hemorrhage)Always assess volume status first when a patient presents with acute kidney injury.
Reliable Historian PrincipleContacting PCP or PharmacistNon-emergent medication reconciliationIn non-urgent settings, use reliable healthcare sources for history rather than family members.
Patient Autonomy/DNR StatusExplicitly stated refusal of life supportAdvanced Directives (Living Will)A patient's current wishes are paramount and supersede the surrogate decision maker's wishes.

Rapid review table

TopicKey PointContextExam Relevance
PE WorkupHigh D-dimer + Acute DyspneaWhen PE is suspected but CXR/EKG are normal.Helps rule out other causes; requires clinical correlation (Wells score).
Pre-renal AKIUrine specific gravity > 1.030, OliguriaDehydration or hypovolemia.Indicates the kidney is attempting to conserve fluid and concentrate urine.
Medication ReconciliationContacting Pharmacist/PCP firstNon-emergent setting with cognitive impairment.Avoids making assumptions about medication changes; emphasizes reliable sources.
Pressure Ulcer CareImmobility, IschemiaAny ulcer progressing to muscle or bone.Requires aggressive wound care and debridement; staging is less useful than recognizing the cause (pressure).

Board-speak -> diagnosis

Board-speak / Vignette phraseDiagnosis / ConceptWhy it fits
Acute dyspnea with normal CXR and markedly elevated D-dimer, but negative cardiac enzymes.Pulmonary Embolism (PE)PE is the most likely cause of acute respiratory distress when classic signs of heart failure or pneumonia are absent.
Oliguria and concentrated urine specific gravity following vomiting/diarrhea.Pre-renal Acute Kidney Injury (AKI)Volume depletion reduces renal perfusion pressure, leading to decreased GFR and concentrating the remaining urine.
Elderly patient with acute GI bleeding and altered mental status in a facility setting.Prioritize contacting the Healthcare ProxyIn non-emergent situations involving impaired cognition, consulting the designated proxy is the ethical first step before invasive procedures or restraints.
Patient explicitly refuses life support measures (e.g., dialysis) while currently lucid.Respect for Patient Autonomy/DNR StatusA patient's current, stated wishes override those of a surrogate decision maker, regardless of advanced directives.
Elderly man with prolonged hospitalization and immobility presenting with a foot lesion.Pressure Ulcer (Ischemic Injury)The primary underlying cause is sustained pressure leading to tissue ischemia; the stage/infection status does not change the root etiology.

Differential diagnosis / distinguishing features

Acute Dyspnea Causes

Key FeaturesDistinguishing FindingsNext Step
Pulmonary Embolism (PE)Tachycardia, High D-dimer, acute onset dyspnea.CT Pulmonary Angiogram (CTPA) if stable; Anticoagulation therapy.
Heart FailureCrackles/rales on lung exam, peripheral edema, elevated BNP.Diuretics and vasodilators (e.g., Nitroglycerin).
COPD ExacerbationHistory of smoking/chronic cough, increased sputum production.Bronchodilators (Albuterol) and systemic steroids; Oxygen therapy.

Management pearls

  • DNR Status: Always respect the patient's current, explicit wishes regarding life support over those stated in an advanced directive or by a surrogate decision maker.
  • Pressure Ulcer Management: If an ulcer is deep (Grade III/IV) and involves muscle or bone, aggressive wound care and surgical debridement are necessary; do not wait for signs of infection to act.
  • Medication Reconciliation: In non-emergent settings with cognitive impairment, the safest initial step is contacting the patient's pharmacist or PCP to verify current medication regimens before making changes.
  • Acute GI Bleeding (Elderly): When managing an elderly patient with acute bleeding and altered mental status, prioritize establishing a clear communication pathway with the healthcare proxy/HCP over immediate invasive procedures or restraints.

Don't miss

🚨
The primary cause of AKI in dehydration is reduced renal perfusion pressure, leading to decreased GFR and concentrating urine (pre-renal).
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In ethical decision-making, autonomy trumps beneficence when a competent patient has made clear refusal of treatment.
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Benzodiazepines should be used with extreme caution or avoided entirely when treating delirium, as they can paradoxically worsen confusion.

Integration & clinical reasoning

  • Cardiology/Pulmonology: The constellation of acute dyspnea and elevated D-dimer is highly suggestive of PE; this requires immediate consideration for anticoagulation therapy (e.g., Heparin).
  • Nephrology: Understanding the difference between pre-renal, intrinsic, and post-renal AKI guides initial management—the first step is always assessing volume status.
  • Ethics/Geriatrics: The principle of respecting patient autonomy requires that clinicians confirm the patient's current wishes directly, even if a surrogate decision maker disagrees.

OMM / COMLEX integration

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For COMLEX: know these viscerosomatics / Chapman points, but don't let OMM distract from emergent diagnosis and management.
  • Acute Illness Management: In any acute, unstable situation (e.g., severe PE or AKI), standard emergency stabilization protocols take absolute priority over OMM techniques.
  • Ethical Care: The principle of patient autonomy and informed consent must guide all care decisions; the clinician's role is to advocate for the patient's stated wishes above institutional or family pressure.

Concept connections / cross-references

  • No explicit cross-references.

High-yield association table

ConditionAssociationMechanismClinical Significance
PEAcute dyspnea, TachycardiaDeep vein thrombosis (DVT) leads to embolization.High suspicion requires immediate workup and potential anticoagulation.
Pre-renal AKIOliguria, Concentrated urine specific gravityDecreased renal perfusion pressure due to hypovolemia.Requires aggressive fluid resuscitation/volume replacement.
Pressure UlcersProlonged immobility, IschemiaSustained pressure compromises capillary blood flow.Debridement is critical; do not rely on staging for diagnosis or treatment plan.
Ethical CarePatient Autonomy > Surrogate Decision MakerThe patient's current, competent wishes are legally and ethically paramount.Always confirm the patient's stated wishes before initiating life-sustaining measures.

Key terms glossary

TermDefinitionContextExample
D-dimerA degradation product of cross-linked fibrin; elevated levels indicate recent coagulation/fibrinolysis.PE workup, trauma, sepsis.Markedly elevated D-dimer in a patient with acute dyspnea suggests thrombosis (PE).
Pre-renal AKIKidney injury due to decreased renal perfusion pressure.Dehydration, hemorrhage, heart failure.Oliguria and concentrated urine specific gravity are classic signs of pre-renal azotemia.
Reliable Historian PrincipleUsing established healthcare sources (PCP, Pharmacist) for history gathering.Medication reconciliation in non-emergent settings.Contacting the patient's pharmacy is safer than asking a family member about medication changes.
Advanced Directive/DNRLegal documents outlining end-of-life wishes; Do Not Resuscitate order.Ethical decision-making, critical care.If a patient explicitly refuses CPR while competent, that wish must be honored regardless of the surrogate's wishes.

Study optimization

TopicStudy ApproachPriorityResources
Acute Cardiopulmonary SyndromesFocus on differentiating causes (PE vs CHF vs Pneumonia). Use labs/imaging to rule out mimics.HighReview PE workup algorithms and clinical scoring systems (Wells score).
Renal Physiology & AKIMaster the three types of AKI (Pre-renal, Intrinsic, Post-renal) based on volume status and urine findings.Medium-HighPractice correlating oliguria/urine specific gravity with underlying causes.
Medical EthicsMemorize the hierarchy: Patient Autonomy > Surrogate Decision Maker. Apply "reliable historian" rule in non-emergent care.HighReview case vignettes focusing on consent, capacity, and end-of-life care.

Question pattern recognition

  • Acute Dyspnea + Elevated D-dimer: Think PE first. If the patient is stable, CTPA is definitive; if unstable, consider empiric anticoagulation based on clinical suspicion.
  • Oliguria/Concentrated Urine (Urine SG > 1.030): Always suspect volume depletion leading to pre-renal AKI. The initial management is fluid resuscitation.
  • Cognitive Impairment & Medication: When reconciling meds for an impaired patient, the most reliable source of information is a professional healthcare provider (pharmacist/PCP), not family members.

Test yourself

Common mistakes to avoid

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Assuming that a high D-dimer confirms PE; it only raises suspicion and requires clinical correlation.
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Believing that all AKI is intrinsic renal failure; always rule out pre-renal causes first by assessing volume status.
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Over-relying on the advanced directive when the patient has recently expressed clear, competent wishes against treatment.

Common traps

⚠️
The "Dementia" Trap: Do not assume a cognitively impaired patient cannot express current, lucid wishes regarding life support; this is critical for autonomy.
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The "Restraint" Trap: Never place restraints or sedatives (especially benzos) on an agitated patient without consulting the proxy and ensuring it is absolutely necessary to prevent immediate harm.
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The "Staging" Trap: Do not waste time memorizing detailed pressure ulcer staging; focus instead on the underlying cause (immobility/pressure) and the need for debridement when deep tissue is involved.

Original transcript with highlights

Original transcript with highlights

Welcome to episode 559 of the Divine Interversion Podcasts. Into this podcast will be continuous series on the USMLE Step 3, 3137. This is going to be Series 6 B. Again, 51 or 54 had a lot of twists and turns and I felt compelled to discuss a bunch of test-ticking principles. So I figured we should do a 6 B and do 55 to 60. Alright, so I'm going to go straight to 55. If you missed out a part of the series, listen to them. Trust me, it's worth your while. Okay, so patient information, age 64 years, this is a 64 year old female. Coming to the office, she says, I can't catch my breath. They won't when I'm sitting still. So look at the HPI, she's going to shut her breath for 12 hours. Has a 15 year history of COPD even her nearly a week ago. Takes out a bit of her all, no allergies, doesn't smoke or drink alcohol. Okay, now look at her labs. I physically examine what stands out. She's tachycardic, she's tecnic, her auto-silence is 86% on rumour, BMI is 23. Her appearance is in acute distress, her intercostal and sternoclydo mastoid muscles are retracted. Honestly, every other exact, she has cardiac exam, she's tachycardic, but every other thing is fine. And then we look at the rest of her labs where D dimer is markedly elevated, is almost like 50x, the upper limit of normal. Every other lab is fine, chest x-ray is fine. So what's the most likely diagnosis, right? So this should make perfect sense to anybody listening to this.

Think about it, this is a person that has like sodium tachycardia, her cardiac enzymes are fine, but her D dimer is elevated. And this thing started acutely, started 12 hours ago. Again, what else do you, as she's present, hypoxic. I've pretty much framed the question for you, this sounds a lot like a PE, right? So I'm going to pick PE, option E is going to be the right answer here. Option A, again, this cannot be a COPD exacerbation. First off, the didn't give us anything about hypercopnea. And a COPD exacerbation, you don't just go from zero to a while. I'm crushing and burning in like just 12 hours. It can happen, but not very commonly. And this person's COPD is not that bad too. You know, they only use it a bit or all, they don't smoke. So the chance of their COPD just exacerbating is not as great as the average individual. This is no heart failure, the BMP is fine. The person doesn't have crackles on a quotation of the long. So they have many, any of the heart failure symptoms, no ordinary D, no peripheral or preliminary DMA. And then this is not pneumonia. Again, you don't go from zero to all, no, dine of pneumonia in 12 hours. That makes no sense. No thorax, kind of the same thing, right? Neymothorax, the chest extra will be abnormal. And the pulmonary exam will be abnormal, right? You have a hyper resonance to precaution and all those things, right? And you have decrysbrate sounds and a certain section of the lungs. So the answer here is E, this is a PE. All right.

So the number to question 56, 20-year-old primary-gravied woman comes to the ED at 8-weeks gestation, because of a 2-day history of persistent nausea and vomiting with a 2-pound weight loss during this time. During this time. She also notes that she has not avoided during the past 8 hours. Oh, she has not peed, okay? She has not had fever, chills or contact with anyone known to be ill. Medical histories are remarkable. She has taken prenatal vitamins sporadically during her pregnancy, but the worsening of nausea and vomiting. Temperature is 98.2, pulse is 90 per minute, respirations are 18 per minute, and blood pressure is 18 over 60. Auto-sad is 99% of the room air, physical exam discloses no abnormalities. Your inspecure gravity is 1.030, which of the full-length lab study results. It's most likely to be abnormal in the patient. All right. So Pshani says, local psychcount, B says LTNST, C says serum calcium, D says serum glucose. E says serum urea nitrogen concentration, and F says normal disease likely. Well, look at this. This is a pregnant lady. And for the past 2 days, so she's at 8 weeks. For the past 2 days, she'll be having nausea, having vomiting. She has lost 2 pounds of weight. That's a lot of weight to lose, and she has not avoided. So she has like, she basically has oligory. That's no good, right? That's no good. And then we see that everything is fine, though. Her vitals are pretty okay. But how urine appears to be very concentrated.

It says that a urine-specure gravity is greater. So it's not 1.030 is greater than 1.030. Remember, urine-specure gravity is a measure of relative density. Specure gravity literally means relative density. It's just a measure of how concentrated your urine is. So basically, we see a person that has been having nausea and vomiting. The person's urine-specure gravity is pretty high, telling you that the urine is pretty concentrated. And the person has not peed for a while. I've pretty much pointed out all the abnormalities here. What does that sound like? Sounds like pre-renol-EKI. When the person has pre-renol-EKI, I'm going to tell you something. The urine is going to be very concentrated, because we usually get pre-renol-EKI in states of volume depletion. And if you have volume depletion, you're not going to be profusing your offering at zero well at all. If you're not, then the hydrostatic pressures within your glomerular capillaries will be decreased. And if that happens, your GFR will decrease. So your BUN is going to rise, and your creatine is going to rise. All right. So the thing that's going to be abnormal here, I'm going to vote for option E here. The serum urine nitrogen concentration. The serum glucose concentration doesn't really make any sense. We're not talking about a woman that has diabetes, you know, like a diabetic mom. Serum calcium, that doesn't make any sense, right? We don't have any signs of symptoms of hypercalcemia or hypocalcemia. LTEST option B.

We'll be shooting for that. If they are giving you a question about those problems like interoperic holostasis of pregnancy or acute fat level of pregnancy or help syndrome. But those things are things that usually show up like after 20 weeks of gestation, not at eight weeks. And they look like, no, she doesn't appear to have any infection. All right. So I'm going to go to question 57. She says, a 60 year old woman who leaves alone is brought to the ED on a Friday evening by her next door neighbor. Who says the patient has fallen several times during the past several days? An emergency department record from a visit one year ago for a minor laceration indicates that the patient has Parkinson's disease with mild dementia by polar disorder and hypertension. Her brother feels her weekly medication organizer, but he's overseas on a business trip for the week. The patient is unable to remember which medication she takes and whether there have been any changes recently to a medication regimen. The neighbor was unable to look at her pillow,ganizer in her home. And her and the patient thinks her brother keeps her pillow bottles at his house to prevent her from inadvertently taking extra doses. She has her brother's address on a card in her wallet along with the names and phone numbers of her primary care physician, psychiatrist and pharmacy. This is a responsible lady actually.

The medical record from her visit one year ago shows that her medications included clonazapam, clonidin and lithium carbonate. Those things of each medication also listed. Attempts to contact the patient's primary care physician and psychiatrist for more detailed medication history have been unsuccessful. Which of the following is the most appropriate initial approach to managing the patient's medications? Option A says ask the police to enter the brother's house to locate the patient's pillow bottles. You don't have a warrant. I would hope you don't do that. That's a way to get sued quickly. Option B says contact the patient's pharmacy to obtain information on her primary medications. Let's keep that. Option C says observe the patient closely well continuing to try to reach her psychiatrist. We've tried to reach the psychiatrist. Why do you want to do that again? That doesn't make any sense. Option D says order the medications as listed in the ED records from her previous visit. What if the doses have changed? That doesn't seem very wise either. Option E says order certain concentrations of the medications listed on the previous emergency department record. Then prescribe doses of the medications and accordance with those concentrations. Again, it doesn't make sense. You're like, oh, let me wait. Well, here's the problem with waiting. What if a situation keeps getting worse? What if it takes a day, two days, three days for those labs to come back?

Does that seem like a wise thing to do? No. So I'm going to go with option B here. And here's why. So this person there for people could get do seen information from we could get it from the primary care physician. We get it from the psychiatrist. We get it from the pharmacy. We could get it from her brother. Now, the first thing I want to ask you is this an emergency situation. Not really. It's not really an emergency situation. So the thing is you have enough time to do the right thing. You don't have to start going gangbusters here. But here's where you need to be very careful. The MBA needs I like to call this the principle of a reliable historian. They love you to go for reliable people when you're trying to clarify information. So like for example, a good classic example of this principle is with ethics where you're. You know, you're trying to get a patient doesn't speak English. You know, doesn't have good language skills and trying to get an interpreter. The MBA means love you to get a certified medical interpreter. If it's a non-emergent situation. So this question kind of mirrors that same principle. Therefore people will get history from PCP psychiatrist pharmacist brother. But we've asked the we've tried to reach the psychiatrist. No go try to reach the PCP no go. So who's the only last reliable historian that's available? It's the pharmacy. They're healthcare professional. They know what's what with the medications reach out to them. Reach out to them.

Chances are pretty good. You probably be able to reach them. The brother no you'll only try to do the reach the brother if it's an emergency situation. But again, the MBA means they generally try to shy away from you contacting unreliable historians. Okay, like the brother in this case because we don't have any indications in this question that the brother is a healthcare professional. So I'm going to keep in mind. Alright, we're going to go to question 58. It's not good. Oh, gross. Okay, so my three year old man is admitted to a nursing care facility from the hospital following a prolonged hospitalization for pneumonia, septicemia and respiratory failure. Medical history is remarkable for advanced dementia, Alzheimer type, hypertension, anti-todibidious mellitus. Career medications include lysinopril, entericated aspirin and insulin-glarging. That's a long act in form of insulin, right? The patient appears free and is confined to bed. Confined to bed. He opens his eyes to voice but is non-communicative. BMI is 27. Temperature is 37.2 degrees Celsius, that's 99 degrees Fahrenheit, pulse is 66 per minute, respirations are 15 per minute. Blood pressure is 142.86 millimeters of mercury. O2 SAD is 97% on room air. Physical examination discloses the finding on the patient's right foot, as shown in the photograph. The remainder of the examination discloses no abnormalities. Which of the following is the most likely underlying cause of this patient's condition?

Again, this question just illustrates what the MBM needs to do a lot of these days. Many questions these days, they don't ask you for street answers, they ask for like the pathophysiology. That's for the mechanism behind those things, right? So, see the gross image I'm going to scroll away from. But again, many times I tell people this, for MBM, questions involving images and stuff. If you just read the question carefully, usually you don't even need the image or the audio or whatever to get the answers right. Most of the time, not all of the time, but most of the time. So, honestly, for this question, I'm going to go, let's look at the answer as option. This is infection with MRSA. No, no. This guy doesn't have fever. We don't get any kind of lucositis. MRSA is a serious infection. We don't see pause or anything coming out. No. Option B says prolonged immobility. I'm going to keep that because we have clear direct evidence of that in the question. This guy's been kind of sitting out for a while. Option C says pyrodomogangrenosa. It could be, when I don't see any histroventilometer about disease, I don't see that classic thing I expect for pyrodomogangrenosa. So, I'm not going to pick that. Option D says systemic atheroembolive. Well, this is something we see with Bluetooth syndrome, where, you know, a person has had like a cardiac cath procedure and then cholesterol crystals.

As you're trying to put that stent, they get removed from the coronary vessel and then they just kind of show around the body. They can begin to occlude tiny vessels and they can cause like Bluetooth. These guys, these guys, big chunk of his food is blue, not just not his toes. All right. Now, option E says venestasis secondary to vavelin competence. First, this is not a woman. This is not chronic venous insufficiency. We don't see the osfer of the medial maliolus. We don't see the lexwellin that is worse by the end of the day because of vavelin competence. This is not, no. This person, no, it's not it. All right. So we're going to skip that. So I'm going to go to option B here, right? This is a pressure ulcer. Again, many people would not believe this. But pressure ulcers can actually be really, really bad. They can be really, really bad depending on how long they've gone on for. Right? They can be really, really bad. Well, the fact that they look very bad on girls doesn't mean that they're infected. They have a high risk of infection, but doesn't mean that they're infected. For this guy though, with how about this is, I have a feeling that the bridment potentially amputation may be in this guy's future. All right. But the end beam is the last that's what I'm going to jump there. All right. But again, this guy needs some heavy wound care and he will almost certainly need the bridment.

Basically, whenever a person has a pressure ulcer, and the ulcer is going so bad that it goes to the level of muscle or bone, the bridment has to be part of your treatment regimen. That's just the truth. You know, many people they try to memorize the different stages of ulcer, stage one, two, three, four. I've generally found that to have very little utility on the USMEL exams. All right. Now, question 59 says 78 year old woman who was admitted to the hospital three days ago, because of worsening renal failure, has become increasingly lethargic and non-responsive. Medical history is significant for type 2 diabetes, hypertension and stroke a year ago with residual right side of weakness and slurred speech. Medications include insulin aspirin and furostamine. On admission, the patient was alert with mildly slurred speech. Shows oriented to person please in time, physical examination disclosed, decreased modus strength, and muscle atrophy in the right operand lower extremities. Results of lab studies showed a sermereanitrogen concentration of 82, and a creatinine concentration of 6.1. Yeah, that's not good. Immodalities was recommended, but the patient declined and expressed an understanding that she would die without intervention. In addition, she requested a do not attempt to resuscitation order. This was documented in a medical record, and her code status was changed to DNR. Sermereanitrogen concentration now is 130, it's getting worse, right?

She has had no urine output during the past 48 hours. That's really bad. The patient's daughter arrives in a state that she is named as the Sargit decision maker by her mother's advanced directive. The daughter insists that he modalities being initiated and the code status be changed to full code, which are the following is the most appropriate course of action. I've dealt with this principle in a previous question from this, I think, from this free 137. The fact that you have a durable power of attorney that you've appointed does not mean you cannot make decisions for yourself. I'm going to say that again, the fact that you do not have a durable, the factory, the fact that you have a durable power of attorney does not mean you cannot make decisions for yourself. This 78-year-old female appears to still be lucid. She has clearly expressed her wishes. I don't want dialysis. I don't want to be resuscitated. But the MBM is, of course, to kind of confuse you, to put the situation of, oh, he has an advanced directive. The advanced directive appoints her daughter as a Sargit. Well, this woman has made a decision. So, it doesn't matter what the advanced directive says, we know her current decision. We know her recent decision. We're going to stick with that. So, basically, the answer we're looking for here is an answer choice that involves us honoring the woman's wishes and not the daughters. Option A says, continue current management do not initiate himodialysis.

I like that answer a lot. But let's look at the other ones. Option B says, initiate himodialysis and change the code status to full code. Nope, I'm not going to do that. Option C says, shake himodialysis, but keep the code status as DNAR until the patient is more alert. Nope, I'm not going to do that. Option D says, obtain consent from the patient's daughter to initiate her medically indicated interventions. The daughter already said what she wants done, but the patient has said what they want done. We need to respect the patient's autonomy. I'm going to go to option A and we're going to move on from that. All right. Question 60. An 88 year old man. An 80 year old woman, sorry, 80 year old woman, is transferred to the emergency department from the nursing care facility where she resides for hours. Four hours after facility staff noted that the patient had a rectal bleeding. Oh, that's no good. Medical history is significant for long-standing dementia, secondary to multiple prior strokes, coronary artery disease, hypertension, hypercholesterolemia, and chronic reno disease. Medications include 81 milligrams of aspirin, sinverstatin, lysinopryl, and hydrochlorothiazide. On arrival in the ED, temperature is 37.2, that's 98.90 degrees Fahrenheit. Post is 102 per minute, transpiration is at 20 per minute, and blood pressure is 105 over 60. Auto SAD is 95% on room air. The patient is awake, but is not oriented to person, place, or time.

She's unable to speak coherently and becomes agitated and combative when a physical examination is attempted. Which of the following is the most appropriate initial intervention? All right. So, option A says, administer lorazapam and proceed with physical exam. Option B says, contact the patient's healthcare proxy to discuss how to proceed. Option C says, place the patient in soft wrist restraints and proceed with physical exam. Option D says, schedule outpatient flexible sigmoidoscopy and discharge the patient. There's one answer here that seems pretty obvious as the right thing to do. So, let's frame this question first. This is an 8-Edeer, or she's pretty old. She's been having a recto bleed in. This person just seems like a person that has a really bad prognosis. Dementia, long standing, lots of strokes. This person's quality of life, their life expectancy is not great. That's just the truth. And as this person is having a recto bleeding, it's kind of high-potensive not doing well. So, this person, chances are, comfort care is what this patient needs. But hey, let's not make those assumptions. That's never a good idea on the USML Es. Let's see what the CDC's answers. Option D, I will not pick option D. I'll patient flex sig. No, this person has an acute illness. This is bad. GI bleeds are no joke. This person could die from it. I'm not going to chill and send this person home. That makes absolutely no sense. Option C says, place the patient in software strings.

Alright, let me tell you this. Val shall not place patients in software strings on the USML Es. If Val do has that, Val shall get in trouble with the MBA mis. Just don't do it. Alright? Option B says, contact the patient's healthcare proxy to discuss how to proceed. That seems like a reasonable answer. I'm going to go to option B. But let's just look at option A to fulfill our righteousness. Option A says, administer lorazapam and pursue a physical exam. No. So, even if this person may be delirious, which may not be the case, delirium, if you had to go to the extent of giving a drug for delirium, you want to give an anti-psychotic. Don't give benzos for delirium. Benzos can paradoxically worsen delirium, not a good idea. So, we'll go to option B. Let's reach out to the proxy, C-O-D-C. Because chances are the pathway we want to go for this lady ultimately is a comfort care. Alright, so that's question 60. Now, before we wrap up, just one quick thing I want to say. And then I'll give a life lesson at the end. If you're interested in any of my review courses, I have a bunch coming up a week from today. For step one to step three, I have a test taking class on the 21st of this month. Bio-starts class on the 22nd of this month. Social science and ethics class on the 23rd of this month. And then for step two and three specifically, I have a three hour last mini review, three hour last mini primer. And I have a 20 hour review for step two, step three.

First of June, I have a 100 hour step two step three class. If you're interested in any of these classes, just shoot me an email. Again, very soon, I'm going to make a podcast where I talk about the 100 hour step two step three class. Actually, opened up signups already. Because there are limited spaces available for that one. But I'll make a full podcast where I talk about the 100 hour class shortly here. Again, these classes, if you're interested, I have a podcast I made where I talked about what you're going to get from these classes, how these classes differ from my podcasts. And again, I'll tell you these these classes are regularly heavily updated. I've had tons of people take these classes and they've done extremely well. I've had 260s, 250s, 270s. I'll save you overwhelming majority of who would I take my classes do really well. I've got in feedback from many different people. And again, it's not a steel class. I try to stick with what the NV Me's are doing at pretty much every point in time. That's why it's updated very regularly. And nothing I will also say is this. The classes may seem short, but they're actually very effective. They're actually very, very effective, very, very effective. And again, I don't just throw facts at you. I give you a context. I explain pathophysiology with these classes. Alright, so if you're interested, shoot me an email through the website. I can give you some more information. And then I have this podcast on Apple Google on Spotify.

So check those out. I have a You Tube channel, divine intervention, USMD podcast and videos, where I post the videos that I make. And then I also have another website called divineinterventionlifelessens.com. Every week I post one or two podcasts where from a biblical perspective, address a life lesson. So divineinterventionlifelessens.com is actually an Apple podcast associated with that. God divine intervention life lessons podcast. And then also I offer one I want you to learn for all the USMD and complex exams. And I also help people with US applications, rec letters, personal statements, walking, reviews and things like that. Now my life lesson is to pay attention to the little things. I feel like people despise their little beginnings. People are always thinking of the big goal, the major score. But they don't realize that that major score generally will not come if you've not been a good steward of the little beginnings. In fact, there's a part of the Bible that says that don't despise the days of little beginnings. Don't despise the days of little beginnings. Many people despise those days of little beginnings. What does it mean to despise something? To despise something basically means you don't take it seriously. It means you're not a good steward of that thing. But the thing is if you pay attention to the little details, you'll notice that over time, those little details you are being serious with will compound and become something big.

Again, compound interest really is the friend of a person that is willing to pay attention to the little details. I like to think of like basketball players. You can just tell that they are certain people that every season, every offseason, they work on little parts of their game and they just become better and better. For example, it's no big secret for you to listen to this podcast and a huge LeBron fan. So whatever team LeBron goes to, I become a fan of that team. So the A.K.A and a Laker fan. So let's look at people like Austin Reeves or people like Max Christie. Shut up to those guys by the way. You notice those guys, they've come into the season, Gones Blazing. Why they come in Gones Blazing? What do you think they did in the offseason? Mester Round? No. They worked on little parts of their game and they became better. Max Christie is not an elite 3-point shooter. He's an elite defender. He can navigate screens really well. Austin Reeves has now become like a legit point guard. You'll probably be an austere this year. Well, if things go right. So I'll just encourage you, take the little things. Take that morning of the two of your dedicated periods seriously. You'll be amazed that just those little things you're taking seriously. Those reviews you're taking seriously. Those following a good sleep schedule are taking seriously. Exercising during your dedicated period. Just those little things.

I'm telling you, you'll be amazed with how quickly it can compound to a very solid USMLE score. Alright, so thank you for listening to me today. I will see you in episode 560 God willing. Have a wonderful week ahead. God bless you and bye for now. Thank you.

Practice questions — USMLE style

Question 1 — Differential Diagnosis

A 64-year-old female presents to the office with acute onset dyspnea, stating she "can't catch her breath" when sitting still. She has a 15-year history of COPD but reports only using an inhaler occasionally and does not smoke. Physical examination reveals tachycardia, tachypnea, and signs of accessory muscle use (retracted intercostal and sternocleidomastoid muscles). Laboratory studies show markedly elevated D-dimer levels (approaching 50x the upper limit of normal), while cardiac enzymes are normal, her BMP is stable, and chest X-ray is unremarkable. What is the most likely diagnosis?

  • A) COPD exacerbation
  • B) Acute heart failure
  • C) Community-acquired pneumonia
  • D) Pulmonary embolism (PE)

Answer: D. The clinical picture strongly suggests a pulmonary embolism (PE). While the patient has risk factors for respiratory distress, the acute onset of severe dyspnea combined with markedly elevated D-dimer and normal findings on cardiac exam/CXR makes PE the most likely diagnosis. COPD exacerbation is less likely given her minimal smoking history and the sudden, dramatic decline over only 12 hours without typical hypercapnia signs. Heart failure is ruled out by the stable BMP and lack of pulmonary crackles. Pneumonia is unlikely due to the acute onset and normal CXR findings.

Question 2 — Physiology

A 20-year-old primary-gravid woman, 8 weeks gestation, presents with a 2-day history of persistent nausea and vomiting (N/V) and has lost 2 pounds of weight. She reports oliguria and notes that her urine appears highly concentrated. Laboratory studies reveal an elevated BUN and creatinine concentration. Which finding is most likely responsible for the abnormal lab results?

  • A) Hypercalcemia, leading to nephrogenic diabetes insipidus
  • B) Hypoglycemia due to poor oral intake
  • C) Pre-renal acute kidney injury (AKI) secondary to volume depletion
  • D) Acute fatty liver of pregnancy causing renal impairment
  • E) Gestational hyperemesis gravidarum causing direct tubular damage

Answer: C. The combination of persistent N/V, weight loss, and oliguria points toward significant volume depletion. This state leads to pre-renal AKI. In response to hypovolemia, the body attempts to conserve fluid by maximally concentrating urine (high specific gravity). Decreased renal perfusion pressure reduces glomerular filtration rate (GFR), leading to an accumulation of nitrogenous waste products (elevated BUN and creatinine). Options A and B are incorrect as there is no evidence of calcium or glucose abnormalities. Option D describes a liver failure syndrome, which typically presents later in pregnancy.

Question 3 — Ethics

A 78-year-old woman with advanced dementia and chronic kidney disease (CKD) was previously assessed and documented her wishes to refuse life support measures, including dialysis, and established a DNR status. She is currently admitted with worsening renal failure and has had no urine output for 48 hours. Her daughter arrives and insists that hemodialysis must be initiated and the code status changed to full resuscitation. What is the most appropriate course of action?

  • A) Honor the patient's documented wishes and continue current management without initiating dialysis or changing the DNR status.
  • B) Initiate hemodialysis immediately, as the surrogate decision-maker (daughter) has asserted her authority.
  • C) Attempt to persuade the daughter that the best outcome is palliative care, regardless of the advanced directive.
  • D) Obtain legal counsel to determine if the daughter's insistence overrides the patient's previously stated wishes.

Answer: A. In medical ethics, a competent patient’s current and documented expressed wishes (advanced directives) take precedence over those of a surrogate decision-maker, even if that surrogate is legally appointed. Since the patient has clearly articulated her refusal of aggressive life support measures while she was still capable of making decisions, her autonomy must be respected.

Question 4 — Clinical Principles

A 60-year-old woman with a history of Parkinson's disease and mild dementia falls multiple times over several days. She is unable to recall which medications she takes or if any regimen changes have occurred. Her brother is unavailable for the week, and attempts to contact her primary care physician (PCP) and psychiatrist have been unsuccessful. Which approach represents the most appropriate initial step in managing this patient's medication regimen?

  • A) Contacting law enforcement to search the brother’s residence for the missing pill organizer.
  • B) Calling the patient's pharmacy to obtain a comprehensive list of her current medications and dosages.
  • C) Observing the patient closely while continuing attempts to reach the psychiatrist, as they are the primary care provider for mental status changes.
  • D) Ordering all medications listed in the previous ED record at the standard doses, assuming no changes have occurred since that visit.

Answer: B. When managing polypharmacy in a geriatric patient with cognitive impairment, the principle of using the "reliable historian" is paramount. Since both the PCP and psychiatrist are unreachable, the pharmacy serves as the most reliable healthcare professional source for current medication information, including dosages and dispensing history. Contacting law enforcement (A) is an overreach without a warrant. Option C wastes time on already failed attempts. Option D risks prescribing outdated or incorrect doses due to potential regimen changes.

Quick fire review

What key finding strongly suggests Pulmonary Embolism (PE)?

Acute dyspnea plus markedly elevated D-dimer, especially if other causes (like CHF/Pneumonia) are ruled out.

In a patient with N/V and oliguria, what is the most likely cause of AKI?

Pre-renal AKI due to volume depletion/hypoperfusion.

What lab finding confirms pre-renal AKI in this scenario?

Elevated BUN/Creatinine ratio (or simply elevated BUN/Cr) with concentrated urine specific gravity.

When reconciling medications for a confused elderly patient, who is the most reliable historian?

A healthcare professional, specifically the dispensing pharmacy or PCP.

If an advanced directive exists and the patient is currently lucid, whose wishes must be honored?

The patient's own current expressed wishes (autonomy).

What should be avoided when treating acute delirium/agitation in the ED?

Benzodiazepines (like lorazepam), as they can paradoxically worsen delirium.

What is the primary differential diagnosis for acute dyspnea with elevated D-dimer and normal CXR?

Pulmonary Embolism (PE).

In pre-renal AKI due to volume depletion, what happens to urine concentration and BUN/Cr?

Urine becomes highly concentrated; BUN and Creatinine levels rise.

What principle guides medication reconciliation in an elderly patient with dementia?

Use the "reliable historian" (e.g., pharmacy records) rather than family memory or old charts.

If a patient has established advanced directives, whose wishes take precedence over a surrogate decision-maker?

The patient's own current expressed wishes (autonomy).

What is the most appropriate initial step when managing an acutely ill, agitated elderly patient with potential GI bleed?

Contacting the healthcare proxy/surrogate decision-maker before any invasive procedure or restraint.

Why are benzodiazepines generally contraindicated in acute delirium management?

They can paradoxically worsen the state of confusion and delirium.

Quick recall / Anki-style questions

What is the primary differential diagnosis for acute dyspnea with elevated D-dimer and normal CXR?

Pulmonary Embolism (PE).

In pre-renal AKI due to volume depletion, what happens to urine concentration and BUN/Cr?

Urine becomes highly concentrated; BUN and Creatinine levels rise.

What principle guides medication reconciliation in an elderly patient with dementia?

Use the "reliable historian" (e.g., pharmacy records) rather than family memory or old charts.

If a patient has established advanced directives, whose wishes take precedence over a surrogate decision-maker?

The patient's own current expressed wishes (autonomy).

What is the most appropriate initial step when managing an acutely ill, agitated elderly patient with potential GI bleed?

Contacting the healthcare proxy/surrogate decision-maker before any invasive procedure or restraint.

Why are benzodiazepines generally contraindicated in acute delirium management?

They can paradoxically worsen the state of confusion and delirium.