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Episode Notes

Source / episode info

  • Episode: 528
  • Title: Divine Intervention Episode 528: 2024 USMLE Step 2 CK Free 120 Discussion Part 9
  • Published: 2024-04-05
  • Source: Episode page

One-liner

This episode provides high-yield review covering ethical principles of patient autonomy, the classic presentation and workup of subcortical stroke, identifying risk factors for post-operative infection in BV, managing acute gout flares, and interpreting positive exercise stress test results.

High-yield summary

  • Patient Autonomy: A competent adult patient's stated wishes must be respected above all other recommendations (family, medical team, legal documents like POA), unless they are proven to lack capacity.
  • Subcortical Stroke: Characterized by simultaneous weakness in both upper and lower extremities on the same side (contralateral to the stroke) due to deep brain structures/spinal tracts being affected below the cortex. HTN is the primary risk factor leading to microaneurysms/hemorrhage.
  • Bacterial Vaginosis (BV): The strongest predisposing risk factor for post-operative infection following D&S CVA is often an active, non-normal vaginal flora, such as BV, indicated by a high pH (>4.5) and malodorous discharge.
  • Gout Management: Acute gout flares are treated primarily with NSAI Ds (if no contraindications), Colchicine, or Corticosteroids. Thiazide diuretics can precipitate gout by interfering with uric acid excretion.
  • Stress Testing: Positive findings on an exercise stress test (e.g., ST segment depression) strongly suggest underlying Coronary Artery Disease (CAD).

Learning objectives

  • Differentiate between patient capacity (legal) and competency (judicial).
  • Recognize the classic motor deficits associated with subcortical vs. cortical strokes.
  • Identify key risk factors for post-operative infection following gynecological procedures, particularly those related to vaginal flora changes.
  • Understand the pathophysiology of gout flares and common precipitating medications/conditions.
  • Interpret positive findings on cardiac stress testing in the context of CAD.

Board exam buzzwords

ConditionKey FindingAssociationBoard Exam Tip
Subcortical StrokeContralateral weakness in U Es & L EsDeep brain structures (basal ganglia, internal capsule)Always suspect this pattern when upper and lower extremities are affected simultaneously.
Bacterial Vaginosis (BV)Vaginal pH > 4.5; White-gray dischargeIncreased risk of post-operative infectionThe active flora imbalance is the strongest risk factor, not just obesity or history.
Gout ArthritisAcute monoarticular joint pain (often MTP joint)Hyperuricemia; Thiazide diuretics/Alcohol intakeTreatment priority: NSAI Ds -> Colchicine -> Corticosteroids.
ST Segment Depression on Stress TestMyocardial IschemiaCoronary Artery Disease (CAD)A positive stress test is the primary indicator of CAD and requires further workup (e.g., angiography).

Rapid review table

TopicKey PointContextExam Relevance
Ethics/LawPatient Autonomy > POACompetent patient voicing wishesThe only time a surrogate decision-maker is used is when the patient lacks capacity (e.g., on ventilator).
StrokeSubcortical pattern: U Es & L Es affected togetherDamage to deep brain structures/internal capsuleDifferentiates from cortical strokes which follow specific vascular territories (MCA for face/UE, ACA for LE).
Infection RiskBV pH > 4.5; White-gray dischargePost-operative infection after D&S CVAThe active flora imbalance is the strongest risk factor compared to obesity or history alone.
GoutThiazide diuretics raise uric acid levelsInterference with renal excretion of urate transportersAlways consider thiazides as a potential trigger for gout flares in high-risk patients.

Board-speak -> diagnosis

Board-speak / Vignette phraseDiagnosis / ConceptWhy it fits
A competent patient insists on going home with visiting nurses, despite the physical therapist recommending a skilled nursing facility.Patient Autonomy/Capacity AssessmentThe patient's current ability to articulate and voice their wishes overrides POA or medical team recommendations.
Stroke presents with weakness in both upper and lower extremities on one side (e.g., left arm and left leg).Subcortical Stroke PatternThis pattern indicates damage below the cortex where the motor tracts for U Es and L Es converge, distinguishing it from cortical strokes (which respect MCA/ACA distributions).
A patient presents with acute monoarticular joint pain in the great toe, associated with hyperuricemia.Gout ArthritisClassic presentation of crystal deposition disease; often triggered by dehydration or certain medications like thiazide diuretics.
Pre-operative infection risk factor for D&S CVA: vaginal discharge pH > 4.5 and white-gray discharge.Bacterial Vaginosis (BV)BV represents an active, abnormal flora imbalance that significantly increases the risk of post-procedure infection compared to other factors like obesity or history alone.
Exercise stress test shows ST segment depression without pain.Coronary Artery Disease (CAD)Stress testing is designed to detect myocardial ischemia; ST depression indicates subendocardial ischemia due to insufficient blood flow during exertion.
A patient with a stroke has increased attenuation in the right putamen on CT scan.Subcortical Hemorrhage/InfarctionThe putamen and basal ganglia are deep, subcortical structures, consistent with the expected location of bleeding or infarct in this pattern.

Differential diagnosis / distinguishing features

Acute Joint Pain (Gout vs. Pseudogout)

Key FeaturesDistinguishing FindingsNext Step
GoutCrystal deposition of Monosodium Urate (MSU); classic presentation in the MTP joint (podagra).Serum uric acid level measurement; aspiration and crystal identification (needle-shaped, negatively birefringent).
PseudogoutCrystal deposition of Calcium Pyrophosphate Dihydrate (CPPD); often affects large joints like knees.Aspiration and crystal identification (rhomboid/square-shaped, positively birefringent).

Management pearls

  • Patient Autonomy: Always prioritize the stated wishes of a competent patient over all other recommendations, including those from family or legal documents (POA).
  • Subcortical Stroke Workup: In any stroke presenting with bilateral UE/LE weakness, assume a subcortical etiology until proven otherwise. High blood pressure is the most common underlying cause due to microaneurysm formation.
  • BV Risk Factor: When assessing infection risk post-D&S CVA, prioritize active vaginal flora abnormalities (pH > 4.5) over systemic factors like obesity or history of prior infections.
  • Gout Treatment: For acute flares, the initial management triad is NSAI Ds, Colchicine, and Corticosteroids. Chronic prevention involves allopurinol/febuxostat to lower uric acid levels.

Don't miss

🚨
Capacity vs. Competency: Capacity is a physical/mental state (e.g., inability to understand instructions); competency is a legal determination made by the courts. A physician assesses capacity, but only a court determines competency.
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Subcortical Stroke Anatomy: The internal capsule and basal ganglia are deep structures; damage here affects motor fibers for both upper and lower extremities simultaneously on one side.
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BV pH: Normal vaginal pH is typically 3.5–4.5. A pH > 4.5 strongly suggests BV, which is a major risk factor for subsequent infections.
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Stress Test Interpretation: ST segment depression during exercise indicates myocardial ischemia/CAD; it does not necessarily mean the patient has angina or that the test was negative.

Integration & clinical reasoning

  • Ethics & Medicine: The principle of autonomy requires clear assessment of capacity. If the patient is competent, their decision must be followed even if medically suboptimal (e.g., refusing necessary care).
  • Endocrinology & Rheumatology: Hyperuricemia and gout are linked to metabolic syndrome and renal function. Thiazide diuretics, commonly used for hypertension, can exacerbate hyperuricemia by impairing urate excretion.
  • OB/GYN & Infection Control: The vaginal microbiome is highly sensitive to pH changes. BV represents a significant deviation from normal flora that increases the risk of ascending infection following invasive procedures like D&S CVA.

Concept connections / cross-references

  • For detailed discussions on stroke workup and vascular pathology, review [ Episode 37 ].
  • For comprehensive coverage of metabolic disorders and renal physiology (including RTA), see [ Episode 15 ].
  • For general guidelines on infectious disease risk factors and microbiology, refer to [ Episode 20 ].

High-yield association table

ConditionAssociationMechanismClinical Significance
Subcortical StrokeHypertension/HTNChronic hypertension leads to microaneurysms in deep cerebral vessels.Hemorrhagic stroke is common; always screen for HTN and risk factors like atrial fibrillation.
Bacterial Vaginosis (BV)High pH (>4.5) & White-gray dischargeDysbiosis of the vaginal flora, loss of protective lactobacilli.Significantly increases the risk of post-operative infection following procedures like D&S CVA.
GoutThiazide DiureticsImpaired renal excretion of uric acid via urate transporters.Clinicians must counsel patients on potential gout flares when initiating thiazides for HTN management.
CAD DiagnosisST Segment Depression on Stress TestSubendocardial ischemia due to insufficient oxygen supply during exertion.A positive stress test is highly suggestive of CAD and requires further cardiac evaluation.

Key terms glossary

TermDefinitionContextExample
Patient AutonomyThe right of a competent individual to make their own medical decisions without coercion.Ethics/Legal MedicineRespecting a patient's refusal of blood transfusion, even if medically advised.
Subcortical StrokeIschemic or hemorrhagic stroke affecting deep brain structures (e.g., basal ganglia, internal capsule).NeurologyWeakness in both upper and lower extremities on one side; often linked to HTN.
Bacterial Vaginosis (BV)A common vaginal dysbiosis characterized by an overgrowth of anaerobic bacteria and a high pH.OB/GYN/Infectious DiseaseRequires treatment with metronidazole or clindamycin before invasive procedures.
HyperuricemiaElevated serum uric acid concentration (>6 mg/dL).Rheumatology/EndocrinologyA major risk factor for gout; monitored in patients taking diuretics like thiazides.

Study optimization

TopicStudy ApproachPriorityResources
Ethics & LawFocus on the hierarchy of decision-making (Patient -> POA -> Family).HighReview case vignettes emphasizing patient competence and autonomy.
Neurology/StrokeMaster the anatomical differences between cortical and subcortical stroke patterns.HighDraw out cerebral artery territories (MCA, ACA) vs. deep brain structures (internal capsule).
Metabolic/InfectionCreate flowcharts for risk factor identification: e.g., D&S CVA -> What is the strongest local risk?Medium-HighReview normal pH ranges and common dysbiotic states (e.g., BV, VVC).

Question pattern recognition

  • Ethical Dilemma: If a patient is fully lucid and competent, their decision must be followed regardless of family or legal documentation (POA/Living Will).
  • Stroke Pattern Clue: Simultaneous weakness in U Es and L Es on one side strongly suggests a subcortical lesion affecting the internal capsule.
  • Gout Trigger: When managing HTN with thiazide diuretics, always counsel the patient about the increased risk of gout due to impaired urate excretion.

Test yourself

Common mistakes to avoid

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Mistake 1 (Autonomy): Assuming that having a Power of Attorney (POA) automatically allows the surrogate to override the patient's current wishes. Correction: POA only activates if the patient is incapacitated.
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Mistake 2 (Stroke): Confusing cortical and subcortical stroke patterns. Correction: Subcortical involves deep structures, affecting U Es/L Es together; Cortical respects vascular territories.
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Mistake 3 (Gout): Believing that all acute joint pain is gout. Correction: Always differentiate between crystal arthropathies (gout vs. pseudogout) and septic arthritis.

Common traps

⚠️
Trap 1 (Ethics): The temptation to choose the legal document (POA) over the patient's current, competent decision. Remember: Competence trumps documentation.
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Trap 2 (Stroke): Focusing only on the most obvious vascular territory (e.g., MCA for face/UE) and ignoring the deep subcortical pattern when U Es and L Es are equally affected.
⚠️
Trap 3 (Infection): Selecting a general risk factor like obesity or history of infection, rather than identifying the active local flora imbalance (BV).

Original transcript with highlights

Original transcript with highlights

Welcome to episode 528 of the Divine Intervention Podcast. My name is Divine. In this episode we're going to be continuing a series on the US Mily Step 2 CK Free 120. This is the most recent one on the US Mily website. And this is going to be part 9. This is going to be part 9. Again, I'm trying to give a fairly detailed discussion of every single question in this series. I've done 65 questions so far. So we're on question 66. So let's go ahead and power up here a little bit. Okay, so question 66. Let's just again, if you've missed any part of the series, I promise you this is a lot of very useful learning. But anyway, okay. So, when a five-year-old man is admitted to the hospital because of a 3 D history of fever, he has type 2 diabetes, malatrous, hypertension, and chronic obstructive coronary disease. One year ago, he had a stroke with residual, right? Lower extremity hemiparises. Medications are amlodipine, tiotropium, metformin, glibipride, lysinoprylonasperin. He does not drink alcoholic beverages and a smoked one pack of cigarettes daily for 50 years. The patient is widowed, lives alone and has three adult children. He is not in a acute distress. He has 178 centimeters, that's 5 foot 10 inches tall, and weighs 82 kilograms, that's 180 pounds. His BMI is 26 kilogram per meter squared. Temperature is 39.2 degrees Celsius, that's 102.6 degrees Fahrenheit. Bulse is 110 per minute, respirations are 22 per minute. And blood pressure is 150 over 90 millimeters of mercury.

Bulse oxygen room air shows an oxygen saturation of 96 percent. Scattered end expiratory whizzies are heard. There is dense hemiparises of the right lower extremity. Appropriate therapy is initiated, and three days later, the patient's condition has improved. He's awake, alert, and conversing with one of his sons about current events. Temperature is 37.2 degrees Celsius, that's 99.0 degrees Fahrenheit. Bulse is 72 per minute, and blood pressure is 130 over 82 millimeters of mercury. Distrash plans a discuss with the patient, his son, the physician, and a physical therapist. The physical therapy says the patient will be best cared for in a nursing care facility. The patient acknowledges that a nursing facility will provide better care for him. Bulse says he will prefer to remain at home with a visiting nurse. Once outside the patient's room, his son says, I have his power of attorney. Don't listen to him. He needs to be in a nursing home. Which of the following is the most appropriate next step? Option A says, inform the son that the decision is the patient's to make, regardless of the medical team's recommendation. Option B says, reassure the son that the patient will be admitted to a nursing care facility. And accordance with the physical therapist's recommendation. Option C says, refrain from making any decisions on telefamily meeting with the son and siblings is arranged to discuss the matter.

Option D says, request psychiatric evaluation of the patient's mental competency. Option C says, request to review the legal documentation, designating the son as having a power of attorney. So what do you think? So in this question, we can clearly see that this person, this patient seems to be pretty, pretty with it. And his voice, he's heard the physician's, the physical therapist's recommendations. And he is voiced his decision. So we got to respect that we have to respect patient autonomy. And it's not like this person is demented or they don't know what's going on. Yeah, yeah, yeah, yeah, yeah. Right. So option A is going to be the right answer. Pissions meet a decision. Yes, voice this decision. He wants to go home and be seen by visiting nurse. So I'm going to do that. So I'm going to go to option A. You know, option B, let's see, we're going to show the son that the patient will be admitted to a nursing care facility. And at court, it's no, you're not respecting patient's autonomy by doing option B. Option C says, refrain from making any decisions on telefamily meeting with the son and siblings is arranged to discuss the matter. You don't need a family meeting. This guy's got him better. He's only like his chicken into a hospice or whatever. Nah, that's wrong. This is a simple question. You got to respect patient autonomy. Option D says, request psychiatric evaluation. Nope, this person doesn't have any signs of being demented or having a mental health disorder.

And then option E says, request to review the legal documentation. Is this getting the son as having power for training? This is a very great, but very wrong answer. Because it may seem like, oh, let's check if the son is right. If the son is right, then, yeah, we got to let the son do what he got to do. But no, see, let me tell you this. There are very few times on the USME Ls where a patient you don't let them make their own decisions. Very, very few. Right. If a patient is with it, even if they've signed a power attorney or whatever, but they're still able to voice their own considerations, then you should always go to the patient's considerations. That is the honest, honest truth. That is what the honest, honest truth. Because I know someone may be like, wow, divine, what if the son was truly the power attorney? It does not matter. The only time where a power attorney is going to kick in is if the patient becomes incapacitated and is like, wow, the person is like out of it. Or the person is on a ventilator, is on a responsive, and they need a decision. Then the power attorney can kick in under those circumstances. That's a very subtle point, but it's a very, very important point to understand. Right. Even if you have a power attorney, even if you have a living will, blah, blah, blah, blah, blah. You, the patient, the decisions and stuff you see in real time, it's going to come more than anything. Right. Even option D is kind of a wrong answer. I mean, option D is wrong.

Right. He says the patient's mental competency. Competency is not something that is determined by a physician. A physician determines capacity. Competency is determined by the courts. Right. You're not a lawyer. You're a physician. Okay. All right. So just kind of make sure you see why 66 is clearly going to be correct. Okay. So let's go to question 67. So a 59 year old man is brought to the emergency department because of a one-on-hiss or weakness of his left arm and leg and mouth headache. All right. He says that when he was guarding with his wife, he suddenly became unable to hold his gardening tool, left his left arm or walk. Two weeks ago, he had a non-productive cough and nasal congestion that resolves spontaneously after one week. He has hypertension treated with lysinopril. On arrival, he is lethargic. He is 100 and 83 centimeters. So that's six foot tall. And weighs 97 kilograms. That's 215 pounds. BMI is 29 kilograms per meter squared. Temperatures 36.6 degrees Celsius. That's 97.90 degrees Fahrenheit. Post is 94 per minute. Respirations are 16 per minute. And blood pressure is 174 over 109. Makes sense. It's having a stroke. The popules measure three millimeters and are reactive to light. Muscle movement is decreased over the left lower aspect of the face. Muscle strength is zero out of five in the left left extremities. Deep tendon reflexes are absent in the left extremities and two plus in the right extremities.

CT scan of the head shows a large area of increase attenuation in the right putemin region, which also follows the most likely cause of the spacial condition. All right, let's look at the answers. Option E says amyloid angiopathy. Option B says embolism. Option C says small vessel disease. Option D says fasculitis. Option E says venos thrombosis. All right, so what do you think? Right? This is a very good example of knowing your concepts, being able to make integrations, understanding pathophysiology, and being a test-taker just all merged perfectly. And to help you in a person answer a question correctly. So like for example, we know this person has a stroke. That's a given. Now what kind of stroke is this? Is it a cortical stroke or a sub cortical stroke? This is a sub cortical stroke. And the way you know that this is a sub cortical stroke is that the persons, operand, and lower extremities are affected at the same time. Right? That's one of the dead giveaways to tell yourself that, oh gee wait, this is a sub cortical stroke versus a cortical stroke. A cortical stroke is a stroke in the cortex. When you have a cortical stroke, you're going to have, you're going to respect cerebral artery distributions. Then I say that again, whenever you have a cortical stroke, you're going to respect what cortical artery cerebral artery distributions. Right?

So like for example, if you're dealing with the middle cerebral artery, you're going to have issues with your upper, with your upper extremities and your face. If you're dealing with the anterior cerebral artery, you're going to be dealing with your lower extremities. Right? But this person has parlysis of the left upper extremities, the left lower extremities. Yeah, they have some face thing going on, whatever. Don't really care too much about that. But the left upper extremities, the left lower extremities are affected. Whenever you see the upper extremities and the lower extremities on the same side affected, that person does not have a cortical stroke. The person has a sub cortical stroke. Because the thing is once you dip below the cortex, the fibers for the upper and the lower extremities, the collocate, this type, the is almost like they're separated, is almost like being single before you get married. And the cortex, the ACA, you know, does lower extremities, MCA does upper extremities and face. They're single then. Once you go below the cortex, you've did it for a long while. Now it's time to get married. So since they've got it married, everything is kind of mixed together. Once you go below the cortex. So that's why you'll notice that, wow, when you have a sub cortical stroke, the upper extremities and the lower extremities on that side are going to be affected. Right? Usually it's going to be contralateral to the stroke. Right?

Because remember, those cortical spinal tract fibers cross. Right? So this person, and usually sub cortical strokes, we're going to find people that have a hypertension. We're going to find people that have hypertension. Right? We're going to find people that have hypertension. Remember, hypertension is the biggest risk factor for strokes. Right? Because when you have hypertension, you can develop these as charcoal, bushard, micro aneurysms. And those micro aneurysms, they can pop. And when you pop, right? That can cause a brain bleed. As we see on imaging in this patient, he says, large area of increase attenuation. When you think that increase attenuation is, that's blood. Right? When the right put him in region, that tells us again that this is what? This is a sub cortical stroke. This is a sub cortical stroke. So those charcoal bushard micro aneurysms, look at what micro. Right? It's usually from small vessels. So the answer is going to be option C. Option C. Well, let's look at the other answers, because I don't want people to just say, oh, divine. You're using option C is right. Let's look at the other answers. Option A. Aminoid angiopathy is wrong. Aminoid angiopathy, we're really finding people that have Alzheimer's or people that have Down syndrome. Right? They can get brain bleed as a result of that. Right? They can get brain bleed as a result of that. Because if you have excess amyloid, right? That amyloid can deposit in the walls of your cerebral vessels.

And when you deposit in those walls, it makes those vessel walls weaker. And when they're weaker, they're going to pop. When they pop, you're going to bleed in your brain. Right? But this person does not have Alzheimer's. This person doesn't have Down syndrome. Remember Down syndrome, you have a ton of amyloid because they have three copies of the gene that goes for anyloid precursor protein. Embellyzen, usually we're going to find that in a person that has a fib or a recent amy. Right? If you have a recent amy, and then because the heart is not contracting properly, they have bloodstasis. Remember, Verkos triad, Verkos triad, they have bloodstasis, and that bloodstasis is going to make them hyperquagulable. Right? And they're going to make an embolus in the heart and then it'll flick up to the brain. We don't see that here. So I'm not going to pick that. Option D says vasculitis. Vasculitis is going to be a chronic process. Right? That makes no sense here. Option E says venos thrombosis. Right? Again, it's highly unlikely that venos thrombosis will cause these kinds of things. You know, you can maybe think of Carvenous sinus thrombosis. That's like a very classic venos thrombosis. They love to test on the exams. But Carvenous sinus thrombosis is going to cause a lot of extrocolomosol problems because a lot of the cranial nerves that could for the extrocolomosols that supply the extrocolomosols may pass through the Carvenous sinus. We don't really see that here.

That's not going to be the right answer. Okay. Question 68 says, a 24-year-old preemigravied woman at 10 Wistia station comes to the office for a scheduled dilatation and suction cure attached. Boy, I hear when people use the word dilatation. It's dilation. But dilatation is right, but I don't know. It just kind of goes on my skin a little bit. But anyway, right? So for the scheduled dilation and suction cure attached. All right. Autosanography two days ago showed a fetus consisting in size with a nine-week gestation with absincardiac activity. Oh, that's not good. Two weeks ago, the patient had an operator-retract infection that results spontaneously. One year ago, she was diagnosed with herpes' simplex virus, too, HSV2. Halasdao Brego is six months ago. She has no other histrosyrosyonis. She's 163 centimeters. That's five foot four inches tall. She weighed 82 kilograms. That's 180 pounds prior to her pregnancy. BMI was 31 kilograms per meter squared. She has had a 3.6 kilogram. That's an eight-pound weight gain during her pregnancy. Vital size only, they normal limits. The over-arrange shavon. No lesions are noted. Examination shows a normal appearing cervix. The uterus is non-tender and consistent in size within eight-week gestation. A lot of stuff here seems pretty normal. But anyway, let's keep going. There's homogenous wide-gray vaginal discharge. The pH of the discharge is 5.5.

She undergoes dilation and suction cure attach with sterile instruments and povidone iodine vaginal clinsic. Which of the four inches the strongest predisposing risk factor for post-operative infection in this patient? All right. So option A says, history of operative retracting infection. Option B says, HSV2. Option C says, Obacillin. Option D says, type of vaginal discharge. Option E says, Vovar shaving. All right. So what do you think this is? These are the kinds of questions that cause people to scratch their heads, pull their hair out on the exam. You don't have to join any of those groups of people. Again, always just ask yourself. What is like really abnormal here? Because you probably heard me as those really questioned that, man, a lot of the stuff is normal. This person unfortunately had an intrauterine fetal demise. The baby is dead. We're bringing out the baby, right? But they're asking, which of course is the strongest predisposing risk factor for post-operative infection? So we just need to ask ourselves, is there anything that is really abnormal in this lady that can cause problems? Well, let's look at some of these things. History of operative retracting infection. Does not abnormal? She had this operative retracting infection two weeks ago. It's cleared. She doesn't have it now. That's not going to be causing problems. HSV2. How last outbreak was six months ago? It's not causing any issues now. So no. Option C says will be city.

Okay, will be city may raise her rate. So let's maybe keep that for now. Option D says type of vaginal discharge. Well, the pH of the discharge is five. Oh, okay. So that's not normal, right? So wait, hang on. So vaginal pH of 5.5 is not normal. It is not normal, honestly. It's not normal. Once your vaginal pH is that deepening to the fives, that is not normal. That is absolutely not normal. If I actually let's look at the discharge, she says, wide-gray vaginal discharge. I wonder what that is. Let's see if you're thinking along with me here. What do you think? Wide-gray vaginal discharge. And the pH is much greater than 4.5. What do you think that is? This one has bacterial vaginosis. All right. So she's got bacterial vaginosis. That's like an actual infection. Okay, so that's not normal. All right. So I'm kind of thinking, I like option D a lot. But let's look at option E. We'll overshave it. You should have a person's over. You've got to do surgery. You've got to keep the air clean. So that's ridiculous. So, you know, I'll come between option C and D, but option D makes sense. It's an actually, she literally has an infection going on. So I'm going to go to option D. Option C is kind of a, because obesity kind of raises your risk with many bad things, you know. But it's not as strong as like an actual infection going on right now. Right? So I'm going to go to option D here. All right. Oh, question 69. Oh, okay. There's a classic one.

A 74 year old woman comes to the clinic two days after the sodium onset of severe left foot pain. She has had difficulty walking during this time and has been using a cane. She has not sustained trauma to the foot. She has type 2 diabetes, malitis and hypertension. Medications are metforming, insulin blargin, hydrochlorothiocyanide, lysinoprylonatroverestatin. So occasionally, she typically wears support stockings because of lower legs swelling. But the foot pain has made it difficult for her to wear them recently. She's a traveling pastor and spends more than four hours leaving her car. She has been monogamous with her wife for the past 30 years. Blood pressure is 146 over 88 millimeters of mercury. All the vital signs are within normal limits. A photograph of the left great toys shown. Great tolle. I wonder what this is. No other abnormalities are noted. Himokyribin A1c7.4%. Serum crafting concentration is 1.4 mixed per deciliter. And serum uric acid concentration is 7.8 mixed per deciliter. It's not only a wonder in the divine, it's not normal or abnormal. I don't know. I guess I gotta look at the table of values. But honestly, I don't care about the table of values. This is a pretty classic case. You really should not be getting these kinds of questions wrong on the exam. Results of serum electrolyte concentrations are within the reference ranges. Which of the following is the most likely diagnosis?

Oceanases, cellulitis, B-sase, gout, C-sase, infected, muhoid-sase, D-sase, osteoarthritis, E-sase, pseudo-gout, F-sase, rheumatoid arthritis. Please don't tell me that you're picking anything other than gout here. Again, the picture is clearly gout. But even if you don't see the picture, great tolle suddenly is hurting. And we see this person is thinking of a thiazide diuretic. The thiazides, they compete for the same transporters that help you excrete uric acid. So the ex-contransporters used to excrete thiazides from your body. Also the same transporters that you insert straight uric acid. So guess what? When you're using thiazide diuretic, so look diuretic, it's not going to raise your uric acid levels. This is going to cause you to have gout. This person has gout. There's no point literally discussing any of the other answers. The answer is gout. Okay? Remember gout, we treated with NSAI Ds. That's it. Gout is treated with NSAI Ds, simplest dot. NSAI Ds, NSAI Ds, NSAI Ds. If NSAI Ds are not an answer, or the person has a contraindication, you can go ahead and put the person on like steroids. Let's do one last question here. So question 70 says, a 47 year old man comes to the office for a routine examination before beginning an exercise program. He feels well. He has a 25 year history of type 1 diabetes mellitus. A grade 1 out of 6 early peak in systolic ejection memories heard best at the left third intercostal space. Sensation to light touches mildly decreased over the toes.

The remainder of these examination shows no abnormalities. An exercise stress test shows three millimeter ST segment depression early in the test. The test does not produce any pain. Which of the following is the most likely diagnosis? So, option A says cardiomyopathy, option B says continental heart disease, option C says coronary artery disease, option D says vascular heart disease, option A says normal cardiac findings. All right, so let's look at this. What do you think is going on here? I mean, this person in this question, let's look through it. It seems to have a, you know, it's getting a stress test. And then this stress test shows an ST segment depression. Well, whenever stress test is positive, it means that coronary vessels are not great, right? So, we're going to go with option C here. So, we're going to go with option C, right? In option B, doesn't make any sense. Conjunctal heart disease, if you want to detect conjunctal heart disease, I don't know, maybe do like an natural structural imaging test of the heart, like an echocardiogram, a vascular heart disease. Again, if you're trying to work on vascular heart diseases, you're going to be doing an echocardiogram, not an exercise, not an EKG based stress test, right? He says, no more cardiac findings. No, STD versions are not no more cardiac findings. Again, he feels, suspect the cardiac myopathy, and I'm going to be doing an EKG for that, he's going to be doing an echocardiogram for that.

And this person also has diabetic neuropathy. So, this is probably looking to that as well. You know, all these diabetics, many times they'll have like this burning, pins and needle sensation in their, in their low extremities. But just something to kind of keep at the back of your mind for, for example. I think I'm going to go ahead and stop here. I would like to keep going on this, like right now. What I have so many responsibilities to do, so I think I'm going to pause on this. But again, the next one, I'll try to make it where I cover more questions. So again, if you love the way I teach, you love the way I make integrations, you love the way I explain my reasoning, you love the way I explain pathophysiology, then you'll be interested in the classes I offer. I have a series of classes that are super helpful for step one, to step three. For step one, to step three, I have a starting on the 18th of this month. I have an NV Me testing and strategy class. It's two and a half hours long. I have a biostat class that's four hours long. I have a social sciences and ethics, quality improvement and healthcare systems class. That's five hours long. These classes are not lectures. If you're expecting lectures, wrong class for you. These classes are based on me discussing clinical scenarios, NV Me style questions extensively. They're pretty much almost all scenarios. And then I'll have these useful charts that I discuss to really get some points across to you.

And I'll help you make a lot of integrations. And then the week after that starting on the 22nd, I have a 20 hours step two step three class. And then in the first week in May, from May 1st to May 5th, I have a 25 hours step one class. Again, I think these classes are going to be super, super helpful for a lot of people. Many people have taken my classes, don't extremely well on the exams. I've had people get, if only the high 270s, I believe I've actually had two 80s from my classes. So again, I think these classes are going to be super helpful to you. If you're interested, just shoot me an email through the website. I'll offer one or one to you, for all the USML and complex exams. Metzical exams and shelf exams. And I help with your applications, recommendation letters, personal statements, and things of that nature. And then I have these podcasts on Apple, Google, and Spotify. So check those out. I have a You Tube channel where I post the videos that I make. And then I would also say that I have another website called at dividinginterventionlifelessons.com. Every week, I post two podcasts, usually on Fridays and Sundays, where from a biblical perspective, I address a life lesson. The podcast about 10 minutes long, you really should check those out. So thank you for listening to me today. I will see you in a episode 529, I guess. Well, God bless you right for now. Thank you.

Practice questions — USMLE style

Question 1 — Neurology

A 59-year-old man presents to the emergency department with sudden onset of weakness in his left arm and leg, accompanied by a headache. He reports that he suddenly became unable to hold gardening tools or walk while gardening. His medical history is significant for hypertension. Physical examination reveals decreased muscle movement over the left lower aspect of the face, zero strength out of five in the left extremities, and absent deep tendon reflexes in the left legs. A CT scan of the head shows a large area of increased attenuation in the right putaminal region. Which of the following is the most likely underlying cause of this stroke?

  • A) Cerebral artery distribution occlusion (cortical stroke)
  • B) Atheroembolism from peripheral plaques
  • C) Charcot-Bouchard microaneurysms due to hypertension
  • D) Vasculitis secondary to systemic lupus erythematosus
  • E) Venous sinus thrombosis

Answer: C. This clinical presentation is classic for a subcortical infarct. The key giveaway that the stroke is subcortical (deep brain structures like the putamen are affected, leading to weakness in both upper and lower extremities on the same side) rather than cortical is the pattern of bilateral motor deficits affecting both sides of the body below the face. Hypertension is the most common risk factor for this type of deep infarct because chronic hypertension leads to microvascular damage, forming Charcot-Bouchard microaneurysms. Rupture of these small aneurysms causes hemorrhagic or ischemic strokes in the subcortical regions.

Question 2 — Rheumatology

A 74-year-old woman presents with acute onset of severe pain and swelling in her left great toe, which has made walking difficult. She has a history of type 2 diabetes mellitus and hypertension. Physical examination reveals an erythematous, hot joint. Laboratory studies show a serum uric acid concentration of 7.8 mg/dL (elevated). The physician notes that the patient is currently taking hydrochlorothiazide for her blood pressure. What is the most likely diagnosis?

  • A) Osteoarthritis
  • B) Pseudogout
  • C) Gout
  • D) Cellulitis
  • E) Rheumatoid arthritis

Answer: C. The classic presentation of acute, severe monoarthritis affecting the great toe (podagra), combined with hyperuricemia and a history of hypertension, strongly suggests gout. Furthermore, the patient is taking hydrochlorothiazide, a thiazide diuretic known to impair uric acid excretion by competing for renal transporters, thereby precipitating or exacerbating gout flares.

Question 3 — OB/GYN

A 24-year-old pre-migravida woman at 10 weeks gestation undergoes dilation and curettage (D&C) following the detection of an intrauterine fetal demise. She has a history of operative retained infection two weeks prior to this procedure, and also reports a vaginal discharge with a pH of 5.5. The patient is scheduled for D&C using sterile instruments and povidone-iodine cleansing. Which of the following findings represents the strongest predisposing risk factor for post-operative infection?

  • A) History of operative retained infection
  • B) Herpes simplex virus (HSV2) history
  • C) Obesity (BMI 31 kg/m²)
  • D) Vaginal discharge pH > 4.5
  • E) Previous D&C procedure

Answer: D. While all listed factors can contribute to increased risk, the most immediate and significant predisposing factor for infection following a cervical or vaginal procedure is an existing local infection. A normal vaginal pH should be acidic (typically <4.5). A pH of 5.5 indicates bacterial vaginosis (BV), which is an actual dysbiosis/infection state that significantly increases the risk of ascending infection and poor wound healing after D&C.

Question 4 — Ethics

A patient, who has been stable for three days following a stroke, is awake, alert, and conversing with his family. He expresses a strong desire to be discharged home to receive care from a visiting nurse. His son, however, insists that the patient must be admitted to a skilled nursing facility, stating, "I have his power of attorney; don't listen to him." Which of the following is the most appropriate next step for the medical team?

  • A) Inform the son that the decision rests solely with the patient, regardless of the medical team’s recommendations.
  • B) Reassure the son that the patient will be admitted to a skilled nursing facility in accordance with the physical therapist's recommendation.
  • C) Arrange a family meeting involving the son and siblings to discuss the matter before making any decisions.
  • D) Request an immediate psychiatric evaluation of the patient’s mental competency status.

Answer: A. The core ethical principle guiding this scenario is patient autonomy. Since the patient is assessed as alert, oriented, and capable of voicing his own wishes (i.e., he has capacity), his decision must be respected, even if it contradicts the medical team's recommendations or the wishes of a family member who holds power of attorney (POA). POA only becomes relevant when the patient lacks capacity (is incapacitated) and cannot make decisions for himself.

Quick fire review

What principle must guide medical decision-making when a patient is competent and able to voice their wishes?

Patient autonomy. The patient's stated preference always takes precedence over family input or professional recommendations.

When does a Power of Attorney (POA) typically become relevant in clinical care?

Only if the patient becomes incapacitated, unable to make decisions for themselves. It does not override current competence.

What is the key difference between "competency" and "capacity"?

Competency is determined by the courts/legal system; Capacity is a determination made by the physician regarding the ability to understand information and make reasoned choices.

What finding on physical exam suggests a subcortical stroke rather than a cortical stroke?

Paralysis affecting both upper and lower extremities on the same side (e.g., left arm and left leg affected). This indicates involvement below the cortex where tracts are mixed.

What is the most common underlying cause of hemorrhagic subcortical strokes in a patient with hypertension?

Rupture of Charcot-Bouchard microaneurysms, resulting from chronic small vessel damage.

In Bacterial Vaginosis (BV), what combination of findings suggests an active infection and increased risk for post-op sepsis?

White-gray discharge and a vaginal pH significantly greater than 4.5.

What is the primary ethical principle that dictates respecting a competent patient's wishes, even if contradicted by family or medical staff?

Patient autonomy.

If a stroke affects both upper and lower extremities on one side, what type of stroke is most likely occurring?

Subcortical stroke (due to mixed tracts below the cortex).

What specific finding in the great toe suggests gout over other causes like cellulitis or OA?

Acute onset, severe monoarticular pain (podagra) combined with hyperuricemia.

In Bacterial Vaginosis, what pH level is considered abnormal and indicative of infection risk?

A pH significantly greater than 4.5 (normal <4.5).

What type of stroke pattern is characterized by respecting the specific territories of major cerebral arteries (e.g., MCA affecting upper body)?

Cortical stroke.

Which condition involves amyloid deposition in vessel walls, leading to potential hemorrhage, but requires a history like Down syndrome or Alzheimer's?

Amyloid angiopathy.

Quick recall / Anki-style questions

What is the primary ethical principle that dictates respecting a competent patient's wishes, even if contradicted by family or medical staff?

Patient autonomy.

If a stroke affects both upper and lower extremities on one side, what type of stroke is most likely occurring?

Subcortical stroke (due to mixed tracts below the cortex).

What specific finding in the great toe suggests gout over other causes like cellulitis or OA?

Acute onset, severe monoarticular pain (podagra) combined with hyperuricemia.

In Bacterial Vaginosis, what pH level is considered abnormal and indicative of infection risk?

A pH significantly greater than 4.5 (normal <4.5).

What type of stroke pattern is characterized by respecting the specific territories of major cerebral arteries (e.g., MCA affecting upper body)?

Cortical stroke.

Which condition involves amyloid deposition in vessel walls, leading to potential hemorrhage, but requires a history like Down syndrome or Alzheimer's?

Amyloid angiopathy.