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Source / episode info

  • Episode: 453
  • Title: Divine Intervention Episode 453: A Quick Review of HY Psychiatry Timelines
  • Published: 2023-04-21
  • Source: Episode page

One-liner

This episode provides a high-yield review of psychiatric diagnostic timelines, emphasizing the precise duration requirements that differentiate conditions like PTSD from Acute Stress Disorder, and Bipolar I vs Bipolar II, while also covering criteria for MDD, GAD, ADHD, and various psychotic spectrum disorders.

High-yield summary

  • PTSD vs ASD: Symptoms must persist for >1 month to meet the criteria for PTSD; if symptoms are present for <1 month following a trauma, it is classified as Acute Stress Disorder (ASD).
  • Adjustment Disorder: Occurs when symptoms develop after an identifiable stressor but do not meet full criteria for another disorder and typically resolve within 6 months of the stressor ending.
  • Bipolar Spectrum: Bipolar I requires mania lasting >1 week (or hospitalization); Bipolar II requires hypomania lasting 4 days. Cyclothymia involves chronic, fluctuating mood symptoms over time.
  • Schizophrenia Stages: The duration of hallucinations dictates the diagnosis: <1 month = Brief Psychotic Disorder; 1-6 months = Schizophreniform Disorder; >6 months = Schizophrenia.
  • MDD Criteria: Requires 5 out of 9 symptoms (including depressed mood or anhedonia) persisting for >2 weeks.
  • Developmental Cutoffs: ADHD must be diagnosed before age 12 and involve symptoms in at least two settings; Conduct Disorder requires the patient to be <18 years old.

Learning objectives

  • Differentiate between Acute Stress Disorder (ASD), PTSD, and Adjustment Disorder based on symptom duration following a stressor.
  • Apply diagnostic criteria for Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD), paying close attention to required timeframes.
  • Distinguish the severity and duration requirements of Bipolar I vs. Bipolar II episodes (Mania vs. Hypomania).
  • Correctly stage psychotic disorders based on the onset and duration of hallucinations (e.g., Schizophreniform vs. Schizophrenia).
  • Identify age-specific diagnostic cutoffs for behavioral disorders, such as Conduct Disorder versus Antisocial Personality Disorder.

Board exam buzzwords

ConditionKey FindingAssociationBoard Exam Tip
PTSDSymptoms >1 month post-traumaTrauma exposure (accident, military)If the timeline is <1 month, immediately consider ASD.
Bipolar I DisorderMania 7 days OR hospitalizationSevere functional impairmentRemember that mania requires a longer duration than hypomania.
Schizophreniform DisorderHallucinations 1-6 monthsPsychotic spectrum disorderThis intermediate stage is often tested to differentiate from Brief and full-blown psychosis.
Conduct DisorderAnti-social behavior in youthAge <18 years oldAlways check the age cutoff when differentiating between conduct/antisocial disorders.

Rapid review table

TopicKey PointContextExam Relevance
PTSD vs ASDDuration is key: >1 month = PTSD; <1 month = ASDExposure to a traumatic event (accident, disaster).High-yield trap question based on the exact time window.
MDD Criteria5/9 symptoms for >2 weeksDepressed mood or anhedonia must be present.Focus on the minimum symptom count and duration required.
Bipolar II vs IHypomania ( 4 days) vs Mania (>7 days)Severity of functional impairment/social dysfunction.The difference in duration is a classic board-style differentiator.
Schizophrenia StagingDuration of hallucinations determines the diagnosis.Psychotic onset following trauma or stress.Memorize the <1, 1-6, and >6 month windows precisely.

Board-speak -> diagnosis

Board-speak / Vignette phraseDiagnosis / ConceptWhy it fits
A trauma victim presents with flashbacks, hyperarousal, and avoidance symptoms lasting 3 weeks.Acute Stress Disorder (ASD)The duration is <1 month, which prevents the diagnosis of PTSD.
A patient reports persistent worry about multiple life domains for over 8 months, but cannot identify a specific stressor.Generalized Anxiety Disorder (GAD)GAD requires symptoms to be present for >6 months and involves excessive, chronic worry across multiple domains.
A young male exhibits aggressive behavior, property destruction, and disregard for rules starting at age 14.Conduct DisorderThis diagnosis is specific to individuals under the age of 18 who display anti-social behaviors.
A patient experiences a manic episode lasting 9 days, requiring hospitalization due to severe impairment.Bipolar I DisorderMania must last >7 days (or require hospitalization) for this diagnosis; hypomania is insufficient.
A college student reports hearing voices and experiencing paranoia that began 4 weeks ago following an intense personal loss.Brief Psychotic DisorderThe duration of hallucinations (<1 month) places the patient in this category, differentiating it from Schizophreniform Disorder.
An adolescent presents with symptoms of aggression and rule-breaking behavior for two years, but is now 20 years old.Antisocial Personality Disorder (ASPD)ASPD is the diagnosis used when conduct disorder criteria are met after age 18.

Differential diagnosis / distinguishing features

Psychotic Disorders (Brief vs Schizophreniform vs Schizophrenia)

Key FeaturesDistinguishing FindingsNext Step
Hallucinations present for <1 month following a severe stressor.Short duration of psychosis; symptoms are acute and transient.Rule out substance use or medical causes (e.g., delirium).

Behavioral Disorders (Conduct vs Antisocial)

Key FeaturesDistinguishing FindingsNext Step
Pattern of aggressive, anti-social behavior and rule violation in youth.Diagnosis must be made when the patient is <18 years old.If >18, reclassify to Antisocial Personality Disorder (ASPD).

Management pearls

  • Psychosis: Always rule out substance use or medical causes (e.g., delirium, metabolic derangement) before confirming a primary psychiatric diagnosis.
  • Bipolar Mania Management: Acute mania often requires hospitalization and mood stabilizers/antipsychotics; safety is the priority over precise timeline adherence.
  • MDD Treatment: First-line treatment involves psychotherapy (CBT) combined with SSR Is or SNR Is, adjusting based on severity and comorbidities.
  • ADHD Diagnosis: Requires evidence of impairment in at least two settings (e.g., home and school/work), not just one.

Don't miss

🚨
The distinction between PTSD (>1 month) and Acute Stress Disorder (<1 month) is a critical, high-yield timeline trap.
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GAD requires symptoms of excessive worry for >6 months to be diagnosed; short periods are insufficient.
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Bipolar I mania must last \ge 7 days (or require hospitalization); hypomania only needs \ge 4 days.
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Conduct Disorder is strictly an age-limited diagnosis (<18 years old).

Integration & clinical reasoning

  • Stressors and Mood: Stress can precipitate or exacerbate mood disorders, but the duration of symptoms determines if it's an Adjustment Disorder vs. a primary MDD/GAD.
  • Developmental Context: The diagnostic criteria for behavioral issues (ADHD, Conduct Disorder) are highly dependent on age cutoffs (<12 years; <18 years).
  • Psychosis Continuum: Understanding the temporal progression of psychosis (Brief -> Schizophreniform -> Schizophrenia) helps predict long-term prognosis and required level of care.

OMM / COMLEX integration

🦴
For COMLEX: know these viscerosomatics / Chapman points, but don't let OMM distract from emergent diagnosis and management.
  • Psychiatric Crisis Management: In any acute psychiatric crisis, standard emergency management protocols (safety, stabilization, ruling out intoxication/withdrawal) take absolute priority over OMT principles.
  • Vagus Nerve Stimulation: While not directly covered, the vagus nerve is implicated in mood regulation and stress response; understanding its role can provide context for psychopharmacology.

Concept connections / cross-references

  • For detailed information on general psychiatric assessment, review [ Episode 450 ].
  • The criteria for mood disorders are often discussed in relation to neurobiology; see [ Episode 37 ] for neurotransmitter systems.

High-yield association table

ConditionAssociationMechanismClinical Significance
PTSDTrauma exposure (e.g., combat, accident)Hyperactivation of the HPA axis and amygdala circuit.Requires specific criteria fulfillment regarding intrusion, avoidance, negative alterations in cognition/mood, and arousal.
Bipolar DisorderGenetic predisposition; mood dysregulationDysregulation of monoamine neurotransmitters (serotonin, norepinephrine).Treatment requires careful monitoring due to risks like lithium toxicity or rapid cycling.
SchizophreniaDopaminergic hyperactivityDysfunction in dopamine pathways leading to positive and negative symptoms.Early intervention is crucial for better long-term outcomes.
ADHDNeurodevelopmental disorderImpairment in executive function, particularly prefrontal cortex regulation.Diagnosis requires evidence of impairment across multiple settings (e.g., home, school).

Key terms glossary

TermDefinitionContextExample
Acute Stress Disorder (ASD)Trauma-related symptoms lasting <1 month.Immediate aftermath of a traumatic event.A soldier experiencing flashbacks 2 weeks after combat deployment.
HypomaniaElevated, expansive mood/increased energy for 4 days.Bipolar spectrum diagnosis; less severe than mania.Feeling unusually productive and energetic for a long weekend without causing major social dysfunction.
Schizophreniform DisorderPsychotic symptoms (hallucinations/delusions) lasting 1-6 months.Intermediate stage of psychosis development.A patient experiencing auditory hallucinations for 3 months, but not meeting full criteria for Schizophrenia.
AnhedoniaInability to experience pleasure.Core symptom of Major Depressive Disorder (MDD).Losing interest in hobbies or activities that were previously enjoyable.

Study optimization

TopicStudy ApproachPriorityResources
Timeline DifferentiationCreate flowcharts comparing duration requirements for all major disorders (PTSD/ASD, Bipolar I/II, Schizophrenia stages).HighReview board-style vignettes focusing solely on timeframes.
Diagnostic CriteriaMemorize the minimum symptom count and required duration for MDD ( 5/9 for >2 weeks) and GAD (>6 months).Medium-HighUse flashcards or mnemonic devices to list the symptoms.
Age CutoffsDrill down on age limits (e.g., ADHD <12; Conduct Disorder <18).HighPractice questions that intentionally test these specific developmental boundaries.

Question pattern recognition

  • Trauma Timeline: If trauma exposure is recent, always check the duration: <1 month -> ASD; >1 month -> PTSD.
  • Psychosis Duration: The length of time hallucinations persist dictates the diagnosis (Brief Psychotic Disorder < 1 mo; Schizophreniform 1-6 mo; Schizophrenia >6 mo).
  • Behavioral Age Limits: If a patient is under 18 and exhibits anti-social behavior, suspect Conduct Disorder first.

Test yourself

Common mistakes to avoid

🚫
Mistake 1: Confusing ASD and PTSD. Always check the timeline! If it's less than one month, it is Acute Stress Disorder (ASD), not PTSD.
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Mistake 2: Misinterpreting Bipolar Severity. Remember that mania requires a longer duration/greater impairment threshold than hypomania.
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Mistake 3: Ignoring Age Cutoffs in Behavioral Disorders. Never diagnose Conduct Disorder or ASPD without verifying the patient's age relative to the diagnostic criteria (e.g., <18 for CD).

Common traps

⚠️
Trap 1 (The Duration Trap): A question stating symptoms lasted exactly 6 months is a trap; it must be >6 months for GAD, and 1-6 months for Schizophreniform Disorder.
⚠️
Trap 2 (The Severity Trap): Assuming that any elevated mood state constitutes Bipolar I mania; always check the minimum duration (\ge 7 days) or hospitalization requirement.
⚠️
Trap 3 (The Symptom Overlap Trap): A patient may have symptoms of both MDD and GAD; remember that the primary diagnosis is determined by which core symptom cluster (anhedonia/low mood vs. excessive worry) meets its respective duration criteria first.

Original transcript with highlights

Original transcript with highlights

All right, welcome. My name is Divine. This is a short podcast. It is just going to be one of those podcasts that you can use to very correctly answer many questions with your exams. And this podcast really is dealing with psychiatric timelines. Psychiatric timelines. High-yield psychiatric timelines. High-yield psychiatric timelines. And we know that in psych, especially with a DSM, you need to know certain pathologies, but not just know the pathologies, but know the timelines associated with them. So the first one I'm going to start off with is PTSD. Right? So you're going to see a person that's having a lot of flashbacks, a lot of intensified experiences. And usually it's going to be a person that most have had a history of like some really bad experience. Maybe they were in an accident or they were first responder or they were in the military. And remember, they're going to have those symptoms for more than a month. You need to have symptoms for more than a month for us to see you have PTSD. If you've had those symptoms for less than a month, we call it acute stress disorder. Now, what if they give you a question about a person that has a really bad stressor? When do you think it's going to be a adjustment disorder? Well, the thing is, many people screw up, I just made the disorder an exam. And you don't have to. And I just made the disorder the problem most have ended the stress almost have ended less than six months ago.

The stress almost have ended less than six months ago. You must have ended less than six months ago. Okay? The cause of it, the stressor usually just made the disorder the way I think of it is you're going to have a stressor. And then you have going to have depression or anxiety light. That's the easy way I think about it. You're going to have a stressor plus anxiety or depression light. So you see a person they have a stress relief in their lives. Maybe they get diagnosed with some malignancy or something like that. And then they start having some depressive symptoms or some anxiety symptoms. But you notice that they don't meet the full criteria for diagnosing MDD. Either they don't have five out of nine of the criteria, what's last day for less than two weeks. Or you see them, they don't meet the full criteria for diagnosing GED. When you see the think of a person having an adjustment disorder. I think we're pressing having an adjustment disorder. I think we're pressing having an adjustment disorder. Okay? So in general, their symptoms don't last for more than six months after the stressor has ended. And typically, typically, typically, they have their symptoms, you know, not for very long. Not for very long. I think that's easy to think about it. Now, what if they give you a question about a person that is anxious about multiple domains of their lives? Well, you're going to be thinking about general likes anxiety disorder GED.

Remember GED, you need to have symptoms for more than six months, for us to say that you have general likes anxiety disorder, has to be for more than six months. If it's less than six months, it's not GED, has to be more than six months. And then, what if they give you a question about a person? And the person, again, has very low mood. They have an hedonia and all those things. Well, obviously, that's going to be major depressive disorder. For us to say that you have major depressive disorder, you need to have symptoms for more than two weeks. You need to have five out of nine of the CIGI cap symptoms for more than two weeks. You need to have like sleep problems, loss of interest, guilt, low energy, concentration problems, appetite issues. You're going to have problems with psychomotor retardation and suicidal ideation. And then also, there's low mood. That's one of those. Okay, so if you have five or more out of those nine symptoms for more than two weeks, that's going to tell us that this person has major depressive disorder. And then remember, if you're looking at depression, and a person has low level depression for more than two years as an adult, we call it dysphemia. Although these days, we call it persistent depressive disorder. Although in children are adolescents, we actually modify that. We actually use more one year, one year for children are adolescents.

And then, if you're talking about a person that is manic, and we're like, ooh, list the diagnosed and we borderline personality disorder. Before we diagnose you with bipolar disorder, you must have had symptoms of mania for more than a week. At least bipolar one, most have had symptoms of mania for more than a week. Although if you require hospitalization for your manic symptoms, we don't wait for a week. It doesn't matter the time frame in those circumstances. Now, bipolar two is when you have hypomania, hypomanic symptoms for at least four days, for at least four days. To be completely honest with you, one of the big differences between mania and hypomania is that people that have hypomania, they don't necessarily have problems in social, they don't usually have like social dysfunction. But people that have mania, they tend to have problems with occupational and social dysfunction. So that's a nice way to differentiate those two things. So again, mania, symptoms more than a week, hypomania, symptoms more than four days. So if we're looking at the longer term form of bipolar disorder, that's going to be called cyclophemia. That's going to be a person that basically has depression and then they have some symptoms of mania, depression and some symptoms of mania, hypomania. So almost like they're moving in cycles for more than two years. But again, kind of like persistent, depressive disorder.

In this case, if you're a child or you're an adult, we use one year, we don't use two years. We use one year, we don't use two years. And typically for cyclophemia, you're not going to have gone for more than two months without having symptoms. You're not going to have gone for more than two months without saying, oh, I do have any symptoms. So that's pretty high, you know. And then remember, I think of such an adolescence, I do disorder that has to be more than six months. Well, don't forget your schizo time-free. So if a person is hearing voices, they have to determine how hallucinations for less than a month. If it's less than a month, we're going to call that birth-psychotic disorder. If it's between one to six months, we call that schizo-frenet from the disorder. If it's more than six months, we call that full-blown schizo-frenet. And then, don't forget, conduct the disorder. We don't say you have conduct the disorder unless you're less than 18. You have to be less than 18 for us to say, oh, gee, you've got conduct the disorder. That's a person that basically has anti-social personality disorder for their under 18. Remember, conduct the disorder is not the same as oppositional defiant. Conduct the disorder to those people, they're screaming at activity, they're violent behavior. Once we go past 18, we're going to call you, oh, jeep, you have anti-social personality disorder. And then, also, ADHD, remember, ADHD typically has to be diagnosed before age 12. Before age 12.

And you need to have those symptoms in at least two settings, right? Those symptoms of hyperactivity and inattentiveness in at least two settings, in at least two settings. As we diagnosed before the age of 12, that's the high yield timeline to keep in mind for ADHD. That's the high yield timeline to keep in mind for ADHD. And then, also, don't forget that if you're thinking of panic disorder, panic disorder, basically, a person will be having a recurring panic attacks. And for more than a month, they'll be worried about having another panic attack. For more than a month, they'll be worried about having another panic attack. Whenever you see something like that, I really, really want to strongly, strongly consider that that person likely has... That person very likely has a panic disorder, okay? That person likely has panic disorder. That person likely has panic disorder. But again, I think in general, if you know these time frames that I've talked about, you should be pretty set with at least the time frames. I mean, there's obviously more stuff with psych, and I have a psych review video on You Tube and also on my website. And I have multiple psychiatric podcasts. And just real quick, if you're taking step two or step three, next week, I do have a review course coming up, studying on Monday and Tuesday, and then Thursday and Friday of next week. It's only 20 hours, five hours each of those days in the evenings in the Easter and Standard time.

And then if you're taking your... You know, if you're taking any of your USML exams, and you need a review for ethics, quality improvement, social sciences, communications, healthcare systems, all those things, I do actually have a class this coming Saturday, next week Saturday, not this Saturday, but next week Saturday, I believe the 29th is a five hour class where we really dive deep into those disciplines. So if you're interested, ship me an email through the website and I'll give you some more information. I'll follow on on one, two, three, and for all the USML exams, step one to three pre-clean comments, for exams, tradition of exams. I do offer review courses for step one, step two and step three. I have a 50 hour review course for step two and step three. Taking place in a... It's a 500 multiple choice question course. Taking place in June, I have an MBME Testikin Strategy course. Many people have taken that I found it to be helpful. That's for two and a half hours. I have a four hour bio statistics board camp, and then I have the five hour social sciences and ethics class. And then I also have a website called, Divine Interventional Life Lessons.com. That's where I post, you know, many of you know, I'm a Christian. I post two podcasts every week on Fridays and Sundays of a life lesson that many people face, but from a biblical perspective. There's actually an Apple Podcast associated with that called Divine Interventional Life Lessons podcast.

And then I also obviously have the podcast for this mainstream podcast on the... on Apple Podcasts, on Google Podcasts, and on Spotify. And also, everything is on Divine Interventional Podcast.com. You don't even actually need a sign in for that. Although, if you have a Word Press account, then you subscribe to my website, and you'll get an email notification whenever I make a new podcast. So thank you for listening to me today. Have a wonderful, wonderful, wonderful rest of your day. I'll see you next time, and bye for now. Thank you.

Practice questions — USMLE style

Question 1 — Psychiatry

A 28-year-old male presents to the emergency department following a severe car accident involving multiple trauma and witnesses. Over the past three weeks, he has reported frequent intrusive memories of the crash, intense feelings of dread when reminded of the event, and significant avoidance behaviors related to driving or cars. He denies having symptoms for longer than three weeks. Based on his current presentation and history, which diagnosis is most appropriate?

  • A) Posttraumatic Stress Disorder (PTSD)
  • B) Acute Stress Disorder (ASD)
  • C) Adjustment Disorder with Anxiety
  • D) Generalized Anxiety Disorder (GAD)

Answer: B. The patient's symptoms are related to a severe stressor (car accident), but the duration is less than one month. According to psychiatric guidelines, if trauma-related symptoms persist for more than four weeks, PTSD is diagnosed; however, if they last for a period of 3 days to one month, Acute Stress Disorder (ASD) is the correct diagnosis.

Question 2 — Psychiatry

A 45-year-old woman is referred to psychiatry by her primary care physician due to changes in mood and energy over the past few months. She reports feeling unusually "high" and energetic, stating she has needed little sleep but feels perfectly fine. Her friends note that she has been excessively talkative, making numerous plans, and spending money on expensive items she cannot afford. However, her occupational functioning remains intact, and she denies any history of severe impairment or hospitalization related to these symptoms. Which diagnosis is most likely based on the duration and severity of her current manic-like episode?

  • A) Bipolar I Disorder
  • B) Cyclothymic Disorder
  • C) Bipolar II Disorder
  • D) Major Depressive Disorder (MDD)

Answer: C. The patient exhibits hypomanic symptoms (elevated mood, decreased need for sleep, increased activity/talkativeness). Crucially, the transcript notes that Bipolar II Disorder is characterized by hypomania, which involves symptoms lasting at least four days but does not cause marked impairment in social or occupational functioning. Mania (Bipolar I) requires symptoms to last more than a week and typically causes significant functional impairment.

Question 3 — Psychiatry

A 12-year-old boy is evaluated for behavioral issues. His parents report that he frequently engages in aggressive outbursts, property destruction, and disregard for the rights of others. The pediatrician notes that these behaviors have been present since childhood and are not limited to a specific setting (e.g., only at school). Which diagnosis should be considered given his age and pattern of behavior?

  • A) Antisocial Personality Disorder
  • B) Oppositional Defiant Disorder
  • C) Conduct Disorder
  • D) Attention-Deficit/Hyperactivity Disorder (ADHD)

Answer: C. The transcript emphasizes that Conduct Disorder is the appropriate diagnosis for aggressive, anti-social behaviors in individuals under 18 years of age. Antisocial Personality Disorder (ASPD), while related, is reserved for diagnoses made after the individual has reached adulthood (over 18).

Question 4 — Psychiatry

A patient presents with persistent feelings of anxiety and worry that are difficult to control. These symptoms have been present for over eight months, affecting multiple domains of her life, including work and relationships. She denies any acute traumatic event or recent major stressor that would explain the onset of these chronic worries. Which diagnosis is most strongly suggested by the duration and pervasive nature of her anxiety?

  • A) Panic Disorder
  • B) Generalized Anxiety Disorder (GAD)
  • C) Adjustment Disorder with Anxiety
  • D) Specific Phobia

Answer: B. The key diagnostic criterion for Generalized Anxiety Disorder (GAD), as highlighted in the transcript, is that symptoms must persist for more than six months. If the anxiety were related to a specific stressor and did not meet full criteria for GAD, it might be considered an Adjustment Disorder; however, the chronic nature over eight months strongly points toward GAD.

Quick fire review

What duration of symptoms defines PTSD?

Symptoms must persist for more than one month following a traumatic event.

If trauma-related symptoms last less than one month, what is the diagnosis?

Acute Stress Disorder (ASD).

For Generalized Anxiety Disorder (GAD), what is the minimum required duration of symptoms?

Symptoms must be present for more than six months.

What is the key difference between Bipolar I Mania and Hypomania regarding social function?

Mania typically causes marked occupational and social dysfunction, whereas hypomania does not necessarily cause such severe impairment.

At what age must Conduct Disorder (CD) be diagnosed?

The individual must be less than 18 years old.

What is the minimum duration of symptoms required for Major Depressive Disorder (MDD)?

Five or more out of nine criteria present for a period exceeding two weeks.

Duration requirement for Acute Stress Disorder?

Less than one month following trauma.

Minimum time needed to diagnose Generalized Anxiety Disorder (GAD)?

More than six months.

What is the minimum duration of hypomanic symptoms required for Bipolar II Disorder?

At least four days.

If a person has low mood and anhedonia for over two years in adulthood, what disorder is suspected?

Persistent Depressive Disorder (PDD).

What time window defines Schizo-frenet Disorder?

Between one month and six months of symptoms.

For ADHD diagnosis, what are the two critical criteria regarding age and setting?

Must be diagnosed before age 12 AND must be present in at least two settings.

Quick recall / Anki-style questions

Duration requirement for Acute Stress Disorder?

Less than one month following trauma.

Minimum time needed to diagnose Generalized Anxiety Disorder (GAD)?

More than six months.

What is the minimum duration of hypomanic symptoms required for Bipolar II Disorder?

At least four days.

If a person has low mood and anhedonia for over two years in adulthood, what disorder is suspected?

Persistent Depressive Disorder (PDD).

What time window defines Schizo-frenet Disorder?

Between one month and six months of symptoms.

For ADHD diagnosis, what are the two critical criteria regarding age and setting?

Must be diagnosed before age 12 AND must be present in at least two settings.